Results 1 to 10 of about 278,652 (177)

Efficacy and safety of pulsatile GnRH pump therapy in male infants with congenital hypogonadotropic hypogonadism [PDF]

Endocrine Connections
Introduction: To investigate the efficacy and safety of pulsatile gonadotropin-releasing hormone pump therapy in male infants with congenital hypogonadotropic hypogonadism.
Xi Wang, Zi Xia Zhang, Jiajia Chen, Dongxia Fu, Mengmeng Du, Yongxing Chen, Haiyan Wei   +6 more
doaj   +4 more sources

Seminal Plasma Metabolomics Signatures of Normosmic Congenital Hypogonadotropic Hypogonadism [PDF]

Heliyon, 2023
Background: Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare disease, whose pathogenesis remains unclear. Here, we conducted untargeted metabolomics and lipidomics to identify seminal plasma signatures of nCHH, and to study the effect ...
Xiaogang Li, Haolong Li, Xueyan Wu
exaly   +5 more sources

Treatment of congenital hypogonadotropic hypogonadism in male patients [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2022
Congenital hypogonadotropic hypogonadism (CHH) is characterized by complete or partial failure of pubertal development because of inadequate secretion of gonadotropic hormones.
Hae Sang Lee, Young Suk Shim, Jin Soon Hwang   +2 more
doaj   +4 more sources

Unraveling Delayed Puberty: A Rare Case of Congenital Hypogonadotropic Hypogonadism Masked by Celiac Disease and Plummer–Vinson Syndrome [PDF]

Clinical Case Reports
Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder that results in delayed puberty and infertility due to impaired secretion of gonadotropin‐releasing hormone (GnRH).
Osama Ahmad, Uzma Akbar, Fatima Sajjad, Muhammad Abdullah Ali, Umama Alam, Zaryab Bacha, Jibran Ikram, Malik W. Z. Khan   +7 more
doaj   +3 more sources

Genetic Architecture of Congenital Hypogonadotropic Hypogonadism: Insights From Analysis of a Portuguese Cohort [PDF]

Human Reproduction Open
STUDY QUESTION What is the contribution of genetic defects in Portuguese patients with congenital hypogonadotropic hypogonadism (CHH)? SUMMARY ANSWER Approximately one-third of patients with CHH were found to have a genetic cause for their disorder, with
Manuel C. Lemos, Carolina Moreno, Luis R. Saraiva   +2 more
exaly   +3 more sources

The Diagnostic Value of the Olfactory Evaluation for Congenital Hypogonadotropic Hypogonadism [PDF]

Frontiers in Endocrinology, 2022
ObjectiveThe aim of this study was to evaluate the diagnostic accuracy of different olfactory evaluation tools in congenital hypogonadotropic hypogonadism (CHH) patients.MethodsSeventy-one CHH patients were prospectively recruited at Peking Union Medical
Sun Bang, Qibin Huang, Kepu Chen
exaly   +4 more sources

Genetic architecture of self-limited delayed puberty and congenital hypogonadotropic hypogonadism [PDF]

Frontiers in Endocrinology, 2023
Distinguishing between self limited delayed puberty (SLDP) and congenital hypogonadotropic hypogonadism (CHH) may be tricky as they share clinical and biochemical characteristics. and appear to lie within the same clinical spectrum.
Valeria Vezzoli, Faris Hrvat, Giovanni Goggi, Silvia Federici, Biagio Cangiano, Biagio Cangiano, Richard Quinton, Richard Quinton, Luca Persani, Luca Persani, Marco Bonomi, Marco Bonomi   +11 more
doaj   +3 more sources

Reversal of Congenital Hypogonadotropic Hypogonadism. [PDF]

J Clin Endocrinol Metab
Context: Congenital genetic disorders have been traditionally considered to be lifelong. An exception to this long-held view is the reversal of congenital hypogonadotropic hypogonadism (CHH).
Dwyer AA, Stamou M.
europepmc   +2 more sources

Identification of Novel Genetic Variants in a Cohort of Congenital Hypogonadotropic Hypogonadism: Computational Analysis of Pathogenicity Predictions. [PDF]

Int J Mol Sci
Congenital hypogonadotropic hypogonadism (CHH) is a rare and heterogeneous genetic disorder with variable penetrance caused by GnRH deficiency, leading to delayed puberty and infertility.
Chiarello P, Gualtieri G, Bossio S, Seminara G, Molinaro M, Antonucci G, Perri A, Rocca V, Cannarella R, La Vignera S, Calogero AE, Greco EA, Iuliano R, Alcaro S, Aversa A.   +14 more
europepmc   +2 more sources

Clinical and genetic characteristics of boys with congenital hypogonadotropic hypogonadism: a single-center experience. [PDF]

BMC Pediatr
Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by deficient secretion or action of gonadotropin-releasing hormone. While its characteristics are well-documented in adults, data from prepubertal patients remain limited.
Fu D, Chen Y, Wu X, Wang H, Gao J, Wei H.   +5 more
europepmc   +2 more sources