The Spectrum of Congenital Hypogonadotropic Hypogonadism: A 30-Year Experience at a Tertiary Paediatric Centre. [PDF]
Clin Endocrinol (Oxf)Congenital hypogonadotropic hypogonadism (CHH) is a rare group of disorders of gonadotropin deficiency, either isolated or as a part of multiple pituitary hormone deficiencies (MPHD).
Kook M, McGee RG, Ambler G, Cho YH.
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The initiation and maintenance of gonadotropin-releasing hormone neuron identity in congenital hypogonadotropic hypogonadism [PDF]
Frontiers in Endocrinology, 2023 Neurons that secrete gonadotropin-releasing hormone (GnRH) drive vertebrate reproduction. Genetic lesions that disrupt these neurons in humans lead to congenital hypogonadotropic hypogonadism (CHH) and reproductive failure.
Wilson CJ Chung, Pei-San Tsai
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Hypogonadotropic hypogonadism due to compound heterozygous mutations TACR3 in siblings
Clinical Case Reports, 2020 The authors present a new association of two heterozygous TACR3 mutations (p.Arg230His and p.Trp275*) responsible for a clinical trait of normosmic congenital hypogonadotropic hypogonadism in a family.
Rita Valsassina +4 more
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Congenital Hypogonadotropic Hypogonadism With Novel Pathogenic Variants in FGFR1 and GNRHR. [PDF]
JCEM Case RepCongenital hypogonadotropic hypogonadism (CHH) can cause delayed secondary sexual characteristics and contribute to juvenile osteoporosis, with multiple causative genes having been reported.
Yamamoto S +5 more
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Comparison of outcomes between pulsatile gonadotropin releasing hormone and combined gonadotropin therapy of spermatogenesis in patients with congenital hypogonadotropic hypogonadism. [PDF]
Reprod Biol EndocrinolTo evaluate whether there was a difference in outcome between pulsatile gonadotropin releasing hormone (GnRH) therapy and human chorionic gonadotropin/human menopausal gonadotropin (hCG/HMG) therapy for induction of spermatogenesis in post-pubertal male ...
Zheng Y +6 more
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Reversible congenital hypogonadotropic hypogonadism: keys for clinical management [PDF]
Archives of Endocrinology and MetabolismCongenitalhypogonadotropic hypogonadism (CHH) is characterized by absent/incomplete puberty and a treatable form of male infertility resulting from deficient gonadotropin-releasing hormone (GnRH) secretion/action. Traditionally, CHH has been considered a
Chrysoula Archaki +2 more
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<i>De novo</i> retrotransposon insertion into the <i>FGFR1</i> gene in a boy with congenital hypogonadotropic hypogonadism: a case report. [PDF]
Front Endocrinol (Lausanne)Congenital hypogonadotropic hypogonadism (CHH) is a rare endocrine disorder characterized by gonadal dysfunction attributed to impaired gonadotropin secretion. CHH is associated with approximately 60 genes including FGFR1.
Sawano K +6 more
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Hypogonadotropic Hypogonadism Revisited [PDF]
Clinics, 2013 Impaired testicular function, i.e., hypogonadism, can result from a primary testicular disorder (hypergonadotropic) or occur secondary to hypothalamic-pituitary dysfunction (hypogonadotropic).
Renato Fraietta +2 more
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Current landscape of fertility induction in males with congenital hypogonadotropic hypogonadism. [PDF]
Ann N Y Acad SciCongenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder caused by deficient secretion or action of gonadotropin‐releasing hormone (GnRH) and is a hormonally treatable form of male infertility.
Dwyer AA, McDonald IR, Quinton R.
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Previously Unrecognized Congenital Hypogonadotropic Hypogonadism in an 89-Year-Old Man: A Case Report. [PDF]
CureusCongenital hypogonadotropic hypogonadism (CHH) is a rare disorder typically recognized during adolescence because of absent or incomplete pubertal development.
Ferreira M +4 more
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