Results 261 to 270 of about 50,076 (346)

Landscape of Somatic and Age‐Related Pathogenic Structural Variations in Hepatocellular Carcinoma Revealed by Long‐Read Sequencing

open access: yesMedComm, Volume 7, Issue 1, January 2026.
This study leveraged long‐read sequencing (LRS) to provide a comprehensive analysis of structural variations (SVs) in the human hepatocellular carcinoma (HCC) genome. Somatic SVs were found to be more prevalent in HBV‐related HCC, with chromosome 1 emerging as the primary hotspot for these alterations. Notably, HBV‐related HCC exhibited a significantly
Zhewen Wei   +24 more
wiley   +1 more source

An Integrated Engineering Approach to Creating Health‐Modulating Postbiotics

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Postbiotics have emerged as a promising alternative to live probiotics, offering comparable health benefits while overcoming challenges related to safety, stability, and shelf life. The review addresses current challenges in standardizing postbiotic definitions and production processes, and by outlining future research directions necessary to unlock ...
Michael Leonidas Chikindas   +10 more
wiley   +1 more source

Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity

open access: yesObesity, Volume 34, Issue 1, Page 127-137, January 2026.
ABSTRACT Objective Severe obesity poses a major public health concern due to its links with cardiometabolic complications and mortality. Visceral adipose tissue (VAT) plays a key role in these processes through distinct molecular features. This study aimed to characterize the VAT proteome of individuals with severe obesity and investigate its ...
Prince Dadson   +10 more
wiley   +1 more source

The Gut Microbiota–Insulin Resistance Axis: Mechanisms, Clinical Implications, and Therapeutic Potential

open access: yesFASEB BioAdvances, Volume 8, Issue 1, January 2026.
Dysbiosis‐induced alterations in microbial metabolite production promote intestinal barrier disruption and systemic inflammation, driving insulin resistance and metabolic dysfunction. Microbiota‐targeting therapies represent promising approaches to restore host metabolic health.
Mohamad Al Qassab   +10 more
wiley   +1 more source

Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults

open access: gold, 2007
Mark A. Tarnopolsky   +7 more
openalex   +2 more sources

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