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Conjugated Linoleic Acids

Current Sports Medicine Reports, 2008
Conjugated linoleic acid (CLA) has been studied extensively in both animal and human models. CLA supplementation has been attributed to provide several health benefits that are based largely upon animal and in vitro studies. Recent literature suggests that CLA supplementation possesses an anti-adipogenic role.
Bill, Campbell, Richard B, Kreider
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Biocatalysis of linoleic acid to conjugated linoleic acid

Lipids, 2006
AbstractCLA refers to a group of geometrical and positional isomers of linoleic acid (LA) with conjugated double bonds. CLA has been reported to have diverse health benefits and biological properties. Traditional organic synthesis is highly capital‐intensive and results in an isomeric mixture of CLA isomers.
Sibel, Irmak   +4 more
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Conjugated linoleic acid metabolism

Current Opinion in Lipidology, 2002
Conjugated linoleic acid (CLA) is a naturally occurring fatty acid that is produced by a bio-hydrogenation process in the rumen, and thus is present in dairy products and ruminant meat. In this case the predominant isomer formed is 9cis,11trans. However, CLA includes 28 positional and geometrical isomers, of which only 9cis,11trans and 10trans,12cis ...
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Adipocyte response to conjugated linoleic acid

Obesity Research & Clinical Practice, 2013
Conjugated linoleic acid (CLA), which is a generic term to describe isomers of octadecadienoic acid, has been reported to exert various beneficial physiological effects. Accumulating data show that CLA, especially trans10, cis12 (t10, c12)-CLA, has a potent body fat-reducing effect, which is prominent in mice and to a lesser extent rats.
Masao, Yamasaki, Teruyoshi, Yanagita
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Biosynthesis of conjugated linoleic acid in humans

Lipids, 2000
AbstractThis paper deals with the reanalysis of serum lipids from previous studies in which deuterated fatty acids were administered to a single person. Samples were reanalyzed to determine if the deuterated fatty acids were converted to deuterium‐labeled conjugated linoleic acid (CLA, 9c, 11t‐18∶2) or other CLA isomers. We found 11‐trans‐octadecenoate
R O, Adlof, S, Duval, E A, Emken
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Conjugated Linoleic Acid and Bone Biology

Journal of the American College of Nutrition, 2000
Osteoporosis, osteoarthritis and inflammatory joint disease afflict millions of people worldwide. Inflammatory cytokines inhibit chondrocyte proliferation and induce cartilage degradation for which part of the response is mediated by PGE2. Excess production of PGE2 is linked to osteoporosis and arthritis and is associated with bone and proteoglycan ...
B A, Watkins, M F, Seifert
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Conjugated linoleic acid and atherosclerosis in rabbits

Atherosclerosis, 1994
Conjugated linoleic acid (CLA) consists of a series of positional and geometric dienoic isomers of linoleic acid that occur naturally in foods. CLA exhibits antioxidant activity in vitro and in vivo. To assess the effect of CLA on atherosclerosis, 12 rabbits were fed a semi-synthetic diet containing 14% fat and 0.1% cholesterol for 22 weeks.
K N, Lee, D, Kritchevsky, M W, Pariza
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Bioconversion of Linoleic Acid into Conjugated Linoleic Acid by Immobilized Lactobacillus reuteri

Biotechnology Progress, 2003
Lactobacillus reuteri was immobilized on silica gel to evaluate the bioconversion of linoleic acid (LA) into conjugated linoleic acid (CLA), consisting of cis-9,trans-11 and trans-10,cis-12 isomers. The amount of cell to carrier, the reaction time, and the substrate concentration, pH, and temperature for CLA production were optimized at 10 mg of cells/(
Sun-Ok, Lee   +2 more
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Kinetics of microbial hydrogenation of free linoleic acid to conjugated linoleic acids

Journal of Applied Microbiology, 2008
To investigate the ability of selected probiotic bacterial strains to produce conjugated linoleic acid (CLA) and also to estimate the biohydrogenation kinetics of Lactobacillus acidophilus on the production of CLA from free linoleic acid (LA).Six probiotic bacteria, Lact. paracasei, Lact. rhamnosus GG, Lact.
H, Xu   +5 more
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Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis

Nutrition and Cancer, 1997
Previous work by Ip and co-workers showed that mammary cancer prevention by conjugated linoleic acid (CLA) is independent of the level of fat in the diet. Because CLA is an isomer of linoleic acid, there is the question regarding whether the effect of CLA is due to a displacement of linoleic acid in cells.
C, Ip, J A, Scimeca
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