Results 71 to 80 of about 1,208,196 (340)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Polarization Conjugated-Phase Component for Sorting Efficiently Vector Beams by Polarization Topological Charge

IEEE Photonics Journal, 2018
Polarization topological charge (PTC) of a vector beam can be defined as the repetition number of polarization state change along the azimuthal axis, with its sign standing for the rotating direction of the polarization.
Shuiqin Zheng, Qinggang Lin, Ying Li, Xuanke Zeng, Yi Cai, Guoliang Zheng, Dianyuan Fan, Shixiang Xu   +7 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Thermodynamic forces, flows, and Onsager coefficients in complex networks

, 2007
We present Onsager formalism applied to random networks with arbitrary degree distribution. Using the well-known methods of non-equilibrium thermodynamics we identify thermodynamic forces and their conjugated flows induced in networks as a result of ...
Agata Fronczak, D. Kondepundi, Janusz A. Hołyst, M. E. J. Newman, Piotr Fronczak, S. Bornholdt, S. N. Dorogovtsev, S. R. Groot   +7 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Nano chloroquine delivery against Plasmodium berghei NK65 induced programmed cell death in spleen

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To compare the protective effects of chitosan-trypolyphosphate (CS-TPP) nanoparticle conjugated chloroquine(CQ) with effect of CQ alone on the reversal of splenic damages and induction of apoptosis.
Satyajit Tripathy, Sourav Chattopadhyay, Sandeep Kr Dash, Motlalepula G Matsabisa, Somenath Roy   +4 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Visualizing the multi-level assembly structures of conjugated molecular systems with chain-length dependent behavior

Nature Communications, 2023
It remains challenging to understand the structural evolution of conjugated polymers from single chains to solvated aggregates and film microstructures, although it underpins the performance of optoelectrical devices fabricated via the mainstream ...
Yang-Yang Zhou, Yu-Chun Xu, Ze-Fan Yao, Jia-Ye Li, Chen-Kai Pan, Yang Lu, Chi-Yuan Yang, Li Ding, Bu-Fan Xiao, Xin-Yi Wang, Yu Shao, Wen-Bin Zhang, Jie-Yu Wang, Huan Wang, Jian Pei   +14 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Driving current through single organic molecules

, 2001
We investigate electronic transport through two types of conjugated molecules. Mechanically controlled break-junctions are used to couple thiol endgroups of single molecules to two gold electrodes.
A. Aviram, A. Nitzan, B. E. Kohler, C. Joachim, C. Joachim, C. Kergueris, C. M. Fisher, D. Beckmann, H. B. Weber, H. v. Löhneysen, J. Chen, J. M. Tour, J. M. van Ruitenbeek, J. Reichert, M. A. Reed, M. Kemp, M. Mayor, Ph. Tamarat, R. M. Metzger, R. Ochs, S. Datta, S. N. Yaliraki, S. N. Yaliraki, U. Banin, V. Mujica   +24 more
core   +1 more source