Results 81 to 90 of about 1,234,343 (276)

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Direct grafting of tetraaniline via perfluorophenylazide photochemistry to create antifouling, low bio-adhesion surfaces. [PDF]

, 2019
Conjugated polyaniline has shown anticorrosive, hydrophilic, antibacterial, pH-responsive, and pseudocapacitive properties making it of interest in many fields. However, in situ grafting of polyaniline without harsh chemical treatments is challenging. In
Aguilar, Stephanie, Chen, Dayong, Curson, Paige A, He, Na, Hoek, Eric MV, Huang, Shu-Chuan, Huang, Xinwei, Jun, Dukwoo, Kaner, Richard B, Lin, Cheng-Wei, Mak, Wai H, McVerry, Brian T, Rao, Ethan   +12 more
core  

Kinetic limitations of cooperativity based drug delivery systems

, 2008
We study theoretically a novel drug delivery system that utilizes the overexpression of certain proteins in cancerous cells for cell specific chemotherapy. The system consists of dendrimers conjugated with "keys" (ex: folic acid) which "key-lock" bind to
Alexei V. Tkachenko, I. G. Campbell, Nicholas A. Licata, S. D. Weitman, S. D. Weitman   +4 more
core   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Targeted delivery of polyamidoamine-paclitaxel conjugate functionalized with anti-human epidermal growth factor receptor 2 trastuzumab

International Journal of Nanomedicine, 2015
Pengkai Ma,1 Xuemei Zhang,1 Ling Ni,2 Jinming Li,2 Fengpu Zhang,1 Zheng Wang,1 Shengnan Lian,1 Kaoxiang Sun1 1School of Pharmacy, Yantai University, Yantai, Shandong Province, People’s Republic of China; 2State Key Laboratory of Long-acting and ...
Ma P, Zhang X, Ni L, Li J, Zhang F, Wang Z, Lian S, Sun K   +7 more
doaj  

Enhancing the Response Speed of Organic Electrochemical Transistors via Ion Liquid/Metal–Organic Framework‐Embedded Semiconducting Polymers

Advanced Electronic Materials
Organic electrochemical transistors (OECTs) are recognized for their ability to combine electronic and ionic transport in the channel, resulting in improved transconductance and reduced operation voltage compared to organic field‐effect transistors ...
Chao‐Hsien Hsu, Sin‐Rong Huang, Jen‐Yu Lai, Gu‐Hao Cai, Meng‐Dian Tsai, Chung‐Wei Kung, Jung‐Yao Chen   +6 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Hausdorff dimension of boundaries of self-affine tiles in R^n [PDF]

, 1997
We present a new method to calculate the Hausdorff dimension of a certain class of fractals: boundaries of self-affine tiles. Among the interesting aspects are that even if the affine contraction underlying the iterated function system is not conjugated ...
Veerman, J. J. P.
core   +4 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Effect of Peptide Derived from Scorpion Toxin on Enhanced Permeability of Doxorubicin Conjugated Gold Nanoparticles in HeLa and MDA-MB-231 Cells

Bihdād, 2020
Background: Cell penetrating peptides (CPPs) can enter a cell through the cell membrane, and used in the fields of drug delivery, gene therapy, and cancer therapy by their property transporting various molecules into cytoplasm.
Sedigheh Khamehchian, Saman Hosseinkhani, Maryam Nikkhah   +2 more
doaj