Results 71 to 80 of about 163,659 (277)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Transmission of Nonconjugative Virulence or Resistance Plasmids Mediated by a Self-Transferable IncN3 Plasmid from Carbapenem-Resistant Klebsiella pneumoniae

Microbiology Spectrum, 2022
Klebsiella pneumoniae poses a critical challenge to clinical and public health. Along with conjugative plasmids, nonconjugative resistance or virulence plasmids associated with carbapenem-resistant K. pneumoniae (CRKP), hypervirulent K. pneumoniae (hvKP),
Xiaoli Wang, Bin Tang, Guitian Liu, Meng Wang, Jingyong Sun, Ruoming Tan, Tingting Pan, Jieming Qu, Jialin Liu, Hong-Yu Ou, Hongping Qu   +10 more
doaj   +1 more source

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism [PDF]

, 2018
C.L.-O. is supported by grants from the European Union (ERC-2016-ADG, DeAge); Ministerio de Economía y Competitividad (MINECO/FEDER: SAF2014-52413-R and SAF2017-87655-R); Instituto de Salud Carlos III (RTICC); Progeria Research Foundation (PRF2016-66 ...
Bárcena Fernández, Clea, Durand, S., Fernández García, María Teresa, Garabaya Fernández, Cecilia, Kroemer, Guido, López Otín, Carlos, Mariño García, Guillermo, Mayoral García, Pablo, Menéndez Caravia, Xurde, Moral Quirós, Pedro, Pérez Freije, José María, Rodríguez, Francisco   +11 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery

Journal of Extracellular Vesicles, 2021
Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting ligands.
Tin Chanh Pham, Migara Kavishka Jayasinghe, Thach Tuan Pham, Yuqi Yang, Likun Wei, Waqas Muhammad Usman, Huan Chen, Marco Pirisinu, Jinhua Gong, Seongkyeol Kim, Boya Peng, Weixi Wang, Charlene Chan, Victor Ma, Nhung T.H. Nguyen, Dennis Kappei, Xuan‐Hung Nguyen, William C. Cho, Jiahai Shi, Minh T.N. Le   +19 more
doaj   +1 more source

Site-specific incorporation of phosphotyrosine using an expanded genetic code. [PDF]

, 2017
Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is key to understanding the role of protein phosphorylation.
Allison Wong, Bing Yang, C Fan, C Hoppmann, Christian Hoppmann, CS Tan, DB Johnson, DT Rogerson, H-G Chao, HS Park, J Xie, JJ Ottesen, JK Takimoto, JP Oza, Kevan M Shokat, L Wang, Lei Wang, M Jbara, MK Tarrant, NL Pirman, P Blume-Jensen, PV Hornbeck, R Serwa, R Yau, RA Chong, S George, SG Julien, Shuwei Li, SJ Humphrey, SW Santoro, T Hunter, T Wauer, Tony Hunter, VK Lacey, WA Lim, Z Chen, Z Xiang   +36 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Gac two-component system in Pseudomonas syringae pv. tabaci is required for virulence but not for hypersensitive reaction [PDF]

, 2008
Pseudomonas syringae pv. tabaci 6605 causes wildfire disease on host tobacco plants. To investigate the regulatory mechanism of the expression of virulence, Gac two-Component system-defective mutants, Delta gacA and Delta gacS, and a double mutant, Delta
A Bultreys, A Chatterjee, A Schaefer, A Stintzi, B Quinones, B Quinones, C Fuqua, DK Willis, EO King, F Taguchi, F Taguchi, Fumiko Taguchi, J Yu, JW Costerton, Kazuhiro Toyoda, KH McClean, LM Keith, M Castaneda, M Elasri, M Marutani, MD Parkins, Md. Mijan Hossain, MF Alexeyev, Mizuri Marutani, NT Keen, PD Shaw, S Heeb, SL Lopez-Garcia, SM Kirov, ST Chancey, T Kitten, TG Kinscherf, TM Barta, Tomonori Shiraishi, WF Fett, Y Ishiga, Yoshishige Inagaki, Yujiro Ogawa, Yuki Ichinose   +38 more
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source