Results 111 to 120 of about 670,162 (341)

Charged Unruh effect on geon spacetimes [PDF]

, 2009
A topological geon black hole with gauge charges may have a gauge bundle that necessarily incorporates charge conjugation as a gauge symmetry. This happens for example for the Reissner-Nordstrom geon. We show that gauging the charge conjugation leaves an
Bruschi, David Edward, Louko, Jorma
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Black Queen Evolution and Trophic Interactions Determine Plasmid Survival after the Disruption of the Conjugation Network

mSystems, 2018
Mobile genetic elements such as conjugative plasmids are responsible for antibiotic resistance phenotypes in many bacterial pathogens. The ability to conjugate, the presence of antibiotics, and ecological interactions all have a notable role in the ...
Johannes Cairns, Katariina Koskinen, Reetta Penttinen, Tommi Patinen, Anna Hartikainen, Roosa Jokela, Liisa Ruusulehto, Sirja Viitamäki, Sari Mattila, Teppo Hiltunen, Matti Jalasvuori   +10 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Topological geon black holes in Einstein-Yang-Mills theory

, 2011
We construct topological geon quotients of two families of Einstein-Yang-Mills black holes. For Kuenzle's static, spherically symmetric SU(n) black holes with n>2, a geon quotient exists but generically requires promoting charge conjugation into a gauge ...
B. Kleihaus, B. Kleihaus, B. Kleihaus, B. Kleihaus, B. Kleihaus, C.W. Misner, E. Radu, G.L. Naber, George T. Kottanattu, H. Stephani, H.-C. Wang, H.P. Künzle, H.P. Künzle, H.P. Künzle, I. Rácz, I. Rácz, J. Louko, J. Louko, J. Louko, J. Louko, J. Louko, J.E. Baxter, J.E. Baxter, J.E. Kiskis, J.L. Friedman, J.L. Friedman, J.M. Maldacena, J.P. Harnad, Jorma Louko, L. Conlon, M. Molelekoa, M. Nakahara, M.S. Volkov, N. Steenrod, N.D. Birrell, P. Bizon, R. Bartnik, R. Sorkin   +37 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Acetaminophen detoxification in cucumber plants via induction of glutathione S-transferases. [PDF]

, 2019
Many pharmaceutical and personal care products (PPCPs) enter agroecosystems during reuse of treated wastewater and biosolids, presenting potential impacts on plant development.
Dudley, Stacia, Gan, Jay, McGinnis, Michelle, Sun, Chengliang, Trumble, John   +4 more
core  

PEG–Peptide Conjugates

Biomacromolecules, 2014
The remarkable diversity of the self-assembly behavior of PEG-peptides is reviewed, including self-assemblies formed by PEG-peptides with β-sheet and α-helical (coiled-coil) peptide sequences. The modes of self-assembly in solution and in the solid state are discussed.
openaire   +2 more sources