Results 111 to 120 of about 285,333 (315)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Bacterial conjugation

, 2016
Bacteria can transfer genetic material, and thus drug resistance, to other bacteria via conjugationEducação Superior::Ciências da Saúde ...
Howard Hughes Medical Institute (HHMI)
core  

Ultrafast click conjugation of macromolecular building blocks at ambienttemperature

, 2009
Block copolymers in seconds: Catalyst-free, ambient-temperature click conjugation of individual polymer strands becomes possible using novel ATRP-derived cyclopentadienylcapped polymers in an extremely rapid hetero-Diels-Alder cycloaddition with ...
Christopher Barner‐Kowollik, Sebastian Sinnwell, Stenzel, M. H., Martina H. Stenzel, Andrew J. Inglis, Sinnwell, S., Barner-Kowollik, C., Inglis, A. J.   +7 more
core   +1 more source

Medium-Chain Lipid Conjugation Facilitates Cell-Permeability and Bioactivity

, 2022
The majority of bioactive molecules act on membrane proteins or intracellular targets and therefore needs to partition into or cross biological membranes.
ByungUk Park (13888726), Reymond, Jean-Louis, Hinnah, K., Morstein, J., Konstantin Hinnah (9402857), Capecchi, Alice, Johannes Morstein (3184269), Van Lehn, Reid C, Jean-Louis Reymond (1296162), Trauner, Dirk, Dirk Trauner, Petit-Jacques, J., ByungUk Park, Alice Capecchi (8257749), Trauner, D., Alice Capecchi, Park, ByungUk, Johannes Morstein, Reid C. Van Lehn, Morstein, Johannes, Petit-Jacques, Jerome, Lehn, R., Reymond, J., Dirk Trauner (549007), Reid C. Van Lehn (6857372), Capecchi, A., Jerome Petit-Jacques (13888729), Park, B., Jerome Petit-Jacques, Jean-Louis Reymond, Hinnah, Konstantin, Konstantin Hinnah   +31 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Preparation of lipase-coated, stabilized, hydrophobic magnetic particles for reversible conjugation of biomacromolecules

, 2013
This Communication presents the development of a novel strategy for the easy conjugation of biomolecules to hydrophobic magnetic microparticles via reversible coating with previously functionalized lipase molecules.
Bolívar Bolívar, Juan Manuel, Filice, Marco, Guisán, José Manuel, Mateo González, César, Mateo, Cesar, Guisan, Jose M., Marciello, Marzia   +6 more
core   +1 more source

Genomic Characterization of a Clinical NDM-1-Producing Klebsiella michiganensis from Brazil

Microorganisms
Public health faces daily challenges due to increasing reports of pathogenic microorganisms with new antimicrobial resistance. Klebsiella michiganensis, an emerging pathogen, poses difficulty in its identification using conventional techniques.
Amanda Yaeko Yamada, Andreia Rodrigues de Souza, Amanda Maria de Jesus Bertani, Karoline Rodrigues Campos, Claudio Tavares Sacchi, Denise Brandão de Assis, Enéas de Carvalho, Elizabeth Harummyy Takagi, Marcos Paulo Vieira Cunha, Monique Ribeiro Tiba-Casas, Carlos Henrique Camargo   +10 more
doaj   +1 more source

Synthesis of Conjugated Polyrotaxanes

Chemistry – A European Journal, 2003
AbstractA series of conjugated polyrotaxane insulated molecular wires are synthesised by aqueous Suzuki polymerisation, using hydrophobic binding to promote threading of the cyclodextrin units. These polyrotaxanes have conjugated polymer cores based on poly(para‐phenylene), polyfluorene, and poly(diphenylene‐vinylene), threaded through 0.9–1.6 ...
Michels, J, O'Connell, M, Taylor, P, Wilson, J, Cacialli, F, Anderson, H   +5 more
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Investigation into the physical and chemical properties of sodium caseinate-maltodextrin glyco-conjugates [PDF]

, 2004
Casein-maltodextrin glyco-conjugates were prepared using an economical, food-grade process based on the Amadori re-arrangement of the Maillard reaction.
Robertson, A. J., Morris, Gordon, Sims, I. M., Furneaux, R. H.   +3 more
core   +1 more source