Results 11 to 20 of about 670,162 (341)

Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence

Nature, 2023
Cap2 of the cyclic dinucleotide-based anti-phage immune system functions through a ubiquitin-like conjugation mechanism to regulate cGAS activity. cGAS is an evolutionarily conserved enzyme that has a pivotal role in immune defence against infection^ 1 –
J. Jenson, Tuo Li, Fenghe Du, Chee-Kwee Ea, Zhijian J. Chen   +4 more
semanticscholar   +1 more source

Attenuating metal-substrate conjugation in atomically dispersed nickel catalysts for electroreduction of CO2 to CO

Nature Communications, 2022
Atomically dispersed transition metals on carbon-based aromatic substrates are an emerging class of electrocatalysts for the electroreduction of CO_2. However, electron delocalization of the metal site with the carbon support via d-π conjugation strongly
Qiyou Wang, Kang Liu, Kangman Hu, Chaoyang Cai, HuangJingWei Li, Hong-mei Li, M. Herran, Ying-Rui Lu, Ting-Shan Chan, Chao Ma, Jun Fu, Shiguo Zhang, Ying Liang, E. Cortes, Min Liu   +14 more
semanticscholar   +1 more source

A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery

Nature Communications, 2022
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the most important mechanisms in mitochondrial quality control (MQC) via the clearance of damaged mitochondria.
H. Tan, Guang Lu, Han Dong, Yik-Lam Cho, Auginia Natalia, Liming Wang, Charlene Chan, Dennis Kappei, R. Taneja, Shuo-Chien Ling, Huilin Shao, Shih-Yin Tsai, W. Ding, Hanming Shen   +13 more
semanticscholar   +1 more source

Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation

Molecules, 2022
The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties.
Agnieszka Potęga
semanticscholar   +1 more source

Improvements of plant protein functionalities by Maillard conjugation and Maillard reaction products

Critical reviews in food science and nutrition, 2021
Plant-derived protein research has gained attention in recent years due to the rise of health concerns, allergenicity, trends toward vegan diet, food safety, and sustainability; but the lower techno-functional attributes of plant proteins compared to ...
R. Naik, Yong Wang, C. Selomulya
semanticscholar   +1 more source

Origins of transfer establish networks of functional dependencies for plasmid transfer by conjugation

Nucleic Acids Research, 2022
Plasmids can be transferred between cells by conjugation, thereby driving bacterial evolution by horizontal gene transfer. Yet, we ignore the molecular mechanisms of transfer for many plasmids because they lack all protein-coding genes required for ...
Manuel Ares-Arroyo, C. Coluzzi, Eduardo P C Rocha   +2 more
semanticscholar   +1 more source

Plasmid Transfer by Conjugation in Gram-Negative Bacteria: From the Cellular to the Community Level

Genes, 2020
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer mechanism through which DNA is transferred from a donor to a recipient bacterium by direct contact.
Chloé Virolle, Kelly Goldlust, Sarah Djermoun, Sarah Bigot, Christian Lesterlin   +4 more
semanticscholar   +1 more source

Novel Self-Transmissible and Broad-Host-Range Plasmids Exogenously Captured From Anaerobic Granules or Cow Manure

Frontiers in Microbiology, 2018
Novel self-transmissible plasmids were exogenously captured from environmental samples by triparental matings with pBBR1MCS-2 as a mobilizable plasmid and Pseudomonas resinovorans as a recipient.
Kosuke Yanagiya, Yoshiaki Maejima, Hiroki Nakata, Maho Tokuda, Ryota Moriuchi, Hideo Dohra, Kengo Inoue, Moriya Ohkuma, Kazuhide Kimbara, Kazuhide Kimbara, Masaki Shintani, Masaki Shintani, Masaki Shintani, Masaki Shintani   +13 more
doaj   +1 more source

Occurrence and a possible mechanism of penetration of natural killer cells into k562 target cells during the cytotoxic interaction [PDF]

, 1995
The cytotoxic interaction between cloned human Natural Killer (NK) cells and K562 target cells was studied using confocal laser scanning microscopy (CLSM) and conventional fluorescence microscopy.
de Grooth, B.G., Figdor, Carl, Greve, Jan, Radosevic, K., Radosevic, Katarina, Segers-Nolten, Gezina M.J., van Leeuwen, Anne Marie T.   +6 more
core   +3 more sources

Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines

Vaccines, 2021
The production of subunit nanovaccines relies heavily on the development of a vaccine delivery system that is safe and efficient at delivering antigens to the target site.
Lantian Lu, Viet Tram Duong, Ahmed O Shalash, M. Skwarczynski, I. Toth   +4 more
semanticscholar   +1 more source