Results 21 to 30 of about 285,333 (315)

Direct Conjugation of Resveratrol on Hydrophilic Gold Nanoparticles: Structural and Cytotoxic Studies for Biomedical Applications

Nanomaterials, 2020
Strongly hydrophilic gold nanoparticles (AuNPs), functionalized with citrate and L-cysteine, were synthetized and used as Resveratrol (RSV) vehicle to improve its bioavailability.
Iole Venditti, Giovanna Iucci, Ilaria Fratoddi, Manuela Cipolletti, Emiliano Montalesi, Maria Marino, Valeria Secchi, Chiara Battocchio   +7 more
doaj   +1 more source

Characterizing conjugative plasmids from an antibiotic-resistant dataset for use as broad-host delivery vectors

Frontiers in Microbiology, 2023
Human microbiome engineering is increasingly proposed as a way to modulate health outcomes. However, one of the current limitations to engineering microbial communities in situ is delivery of a genetic payload for introducing or modifying genes.
Héctor G. Loyola Irizarry, Ilana L. Brito   +1 more
doaj   +1 more source

A purple odyssey: synthesis and structure of 3-amino-4-hydroxy-6-oxocyclohexa-2,4-dien-1-iminium chloride monohydrate

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the cation of the title hydrated molecular salt, C6H7N2O2+·Cl−·H2O, the six-membered ring shows unequal bond lengths consistent with delocalization of electrons over two separate 6π systems with single bonds between them.
M. John Plater, William T. A. Harrison
doaj   +1 more source

Differential Requirement for the Cell Wall Integrity Sensor Wsc1p in Diploids Versus Haploids

Journal of Fungi, 2021
The primary role of the Cell Wall Integrity Pathway (CWI) in Saccharomyces cerevisiae is monitoring the state of the cell wall in response to general life cycle stresses (growth and mating) and imposed stresses (temperature changes and chemicals). Of the
Allison E. Hall, Miriam Lisci, Mark D. Rose   +2 more
doaj   +1 more source

Taming Unhindered Alkyl Azides by Intramolecular Hydrogen-Azide Interaction for Discriminative Conjugation onto Alkyl Diazides

, 2021
We report herein the unique reactivities of α-azido secondary acetamides (α-AzSAs) as minimal and unhindered azide structures. The NH–azide interaction in the α-AzSAs, supposed by DFT calculation, allowed selective conjugation in the presence of other ...
Koshiro, Maegawa, Kiyomi, Kakiuchi, Takenori, Tomohiro, Seiji, Onishi, Hiroki, Tanimoto, Tsumoru, Morimoto   +5 more
core   +1 more source

AJICAP Second Generation: Improved Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugate Production

, 2023
The site-directed chemical conjugation of antibodies remains an area of great interest and active efforts within the antibody-drug conjugate (ADC) community.
Muneki, Isokawa, Sayaka, Kawaguchi, Tatsuya, Okuzumi, Yuri, Ooba, Rika, Takasugi, Yutaka, Matsuda, Natsuki, Shikida, Kazutaka, Shimbo, Tomohiro, Fujii, Tomohiro, Watanabe, Akira, Nakayama, Kei, Yamada, Takuya, Seki, Yusuke, Iwai, Noriko, Hatada, Brian. A., Mendelsohn, Kazutoshi, Takahashi   +16 more
core   +1 more source

Foodborne Microbial Communities as Potential Reservoirs of Antimicrobial Resistance Genes for Pathogens: A Critical Review of the Recent Literature

Microorganisms, 2023
Antimicrobial resistance (AMR) is a global and increasing threat to human health. Several genetic determinants of AMR are found in environmental reservoirs, including bacteria naturally associated with widely consumed fermented foods.
Paola Zinno, Giuditta Perozzi, Chiara Devirgiliis   +2 more
doaj   +1 more source

Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in sumo pathways [PDF]

, 2010
Canonical ubiquitin-like proteins (UBLs) such as ubiquitin, Sumo, NEDD8, and ISG15 are ligated to targets by E1-E2-E3 multienzyme cascades. The Sumo cascade, conserved among all eukaryotes, regulates numerous biological processes including protein ...
Miller, D.J., Asad M Taherbhoy, Schulman, B.A., Darcie J Miller, Steven N Seyedin, Huang Danny T., Wang, J., Kobe, B., Steven N. Seyedin, Seyedin Steven N., David W. Miller, Miller David W., Darcie J. Miller, Hunt Harold W., Miller, D.W., Taherbhoy, A.M., Danny T. Huang, Brenda A. Schulman, Miller Darcie J., Danny T Huang, Wang Jing, Harold W. Hunt, Harold W Hunt, Asad M. Taherbhoy, Schulman Brenda A., Jing Wang, Huang, D.T., Taherbhoy Asad M., David W Miller, Hunt, H.W., Seyedin, S.N., Brenda A Schulman   +31 more
core   +1 more source

Conjugation-Driven “Reverse Mars–van Krevelen”-Type Radical Mechanism for Low-Temperature C–O Bond Activation

, 2016
C–O bond activation on monofunctional catalysts (metals, carbides, and oxides) is challenging due to activity constraints imposed by energy scaling relationships.
Dionisios G. Vlachos (261715), Alexander V. Mironenko (1634152)   +1 more
core   +2 more sources

Reducing Antigenicity and Improving Antioxidant Capacity of β-Lactoglobulin through Covalent Interaction with Six Flavonoids

Foods, 2023
β-lactoglobulin (β-LG) is a pivotal nutritional and functional protein. However, its application is limited by its antigenicity and susceptibility to oxidation.
Pei Pu, Zhifen Deng, Lang Chen, Han Yang, Guizhao Liang   +4 more
doaj   +1 more source