Results 51 to 60 of about 311,139 (302)

Lipid-Based Nanomaterials for Drug Delivery Systems in Breast Cancer Therapy

Nanomaterials, 2022
Globally, breast cancer is one of the most prevalent diseases, inducing critical intimidation to human health. Lipid-based nanomaterials have been successfully demonstrated as drug carriers for breast cancer treatment.
Lekshmi Rethi, Chinmaya Mutalik, Dito Anurogo, Long-Sheng Lu, Hsiu-Yi Chu, Sibidou Yougbaré, Tsung-Rong Kuo, Tsai-Mu Cheng, Fu-Lun Chen   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results

Molecules, 2022
Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the ...
Hanggara Arifian, Rani Maharani, Sandra Megantara, Amirah Mohd Gazzali, Muchtaridi Muchtaridi   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The fine implicative structure of European Portuguese conjugation

Isogloss, 2021
Recent literature has highlighted the extent to which inflectional paradigms are organised into systems of implications allowing speakers to make full use of the inflection system on the basis of exposure to only a few forms of each word.
Sacha Beniamine, Olivier Bonami, Ana R. Luís   +2 more
doaj  

The Lactococcus lactis Pan-Plasmidome

Frontiers in Microbiology, 2019
Plasmids are autonomous, self-replicating, extrachromosomal genetic elements that are typically not essential for growth of their host. They may encode metabolic capabilities, which promote the maintenance of these genetic elements, and may allow ...
Philip Kelleher, Philip Kelleher, Jennifer Mahony, Jennifer Mahony, Francesca Bottacini, Gabriele A. Lugli, Marco Ventura, Douwe van Sinderen, Douwe van Sinderen   +8 more
doaj   +1 more source

IncHI1 plasmids are epidemic vectors that mediate transmission of tet(X4) in Escherichia coli isolated from China

Frontiers in Microbiology, 2023
IntroductionThis study aimed to investigate the genetic factors promoting widespread Q6 dissemination of tet(X4) between Escherichia coli and to characterize the genetic contexts of tet(X4).MethodsWe isolated E.
Yan Zhang, Yan Zhang, Jie Zhang, Jie Zhang, Ping Cai, Ping Cai, Yang Lu, Yang Lu, Ruan-Yang Sun, Ruan-Yang Sun, Meng-Tao Cao, Meng-Tao Cao, Xiao-Li Xu, Mark A. Webber, Hong-Xia Jiang, Hong-Xia Jiang   +15 more
doaj   +1 more source

Structural insights into the membrane-extracted dimeric form of the ATPase TraB from the Escherichia coli pKM101 conjugation system [PDF]

, 2011
Background: Type IV secretion (T4S) systems are involved in secretion of virulence factors such as toxins or transforming molecules, or bacterial conjugation. T4S systems are composed of 12 proteins named VirB1-B11 and VirD4.
Veronique Receveur-Brechot, Durand, E., Waksman, Gabriel, Eric Durand, Receveur-Brechot, V., Gabriel Waksman   +5 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Successful Transfer of a Model T-DNA Plasmid to E. coli Revealed Its Dependence on Recipient RecA and the Preference of VirD2 Relaxase for Eukaryotes Rather Than Bacteria as Recipients

Frontiers in Microbiology, 2018
In Agrobacterium-mediated transformation (AMT) of plants, a single-strand (ss) T-DNA covalently linked with a VirD2 protein moves through a bacterial type IV secretion channel called VirB/D4.
Yuta Ohmine, Kazuya Kiyokawa, Kazuya Yunoki, Shinji Yamamoto, Kazuki Moriguchi, Katsunori Suzuki   +5 more
doaj   +1 more source