Results 51 to 60 of about 285,333 (315)

Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate

, 2022
The covalent fusion of immunostimulatory adjuvants to immunogenic antigens is a promising strategy for the development of effective synthetic vaccines for infectious diseases.
Ismanto, Hendra S, Ashhurst, Anneliese S, Artner, Lukas M, Britton, Warwick J, Hanna, Cameron C, Yamasaki, Sho, Maxwell, Joshua WC, Rudrawar, Santosh, Payne, Richard J   +8 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Antibiotic Resistance, Virulence Factors, Phenotyping, and Genotyping of E. coli Isolated from the Feces of Healthy Subjects

Microorganisms, 2019
Escherichia coli may innocuously colonize the intestine of healthy subjects or may instigate infections in the gut or in other districts. This study investigated intestinal E. coli isolated from 20 healthy adults.
Stefano Raimondi, Lucia Righini, Francesco Candeliere, Eliana Musmeci, Francesca Bonvicini, Giovanna Gentilomi, Marjanca Starčič Erjavec, Alberto Amaretti, Maddalena Rossi   +8 more
doaj   +1 more source

Evolution of Virulence, Fitness, and Carbapenem Resistance Transmission in ST23 Hypervirulent Klebsiella pneumoniae with the Capsular Polysaccharide Synthesis Gene wcaJ Inserted via Insertion Sequence Elements

Microbiology Spectrum, 2022
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is recognized as a threat worldwide, but the mechanisms underlying its emergence remain unclear. As most CR-hvKP isolates are not hypermucoviscous, we speculated that the evolution of the
Shuyi Wang, Qi Ding, Yawei Zhang, Anru Zhang, Qi Wang, Ruobing Wang, Xiaojuan Wang, Longyang Jin, Shuai Ma, Hui Wang   +9 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Carboxyl-Terminal Amino Acids Render Pro-Human LC3B Migration Similar to Lipidated LC3B in SDS-PAGE [PDF]

, 2013
LC3 is widely used marker for macroautophagy assays. After translation pro-LC3 is processed by Atg4 to expose C-terminal glycine residue for downstream conjugation reactions to accomplish the conversion of LC3-I to LC3-II. SDS-PAGE based Western blot (Wb)
Wang, W, Billiar, Timothy R., Chen, Z, Gao Wentao, Wang, Wei, Timothy R Billiar, Billiar, TR, Billiar Timothy R., Gao, Wentao, Zhixia Chen, Wentao Gao, Wang Wei, Stang Michael T., Chen, Zhixia, Michael T Stang, Timothy R. Billiar, Gasset, Maria, Michael T. Stang, Gao, W, Wei Wang, Stang, MT, Stang, Michael T., Chen Zhixia   +22 more
core   +1 more source

Dissemination of antimicrobial resistance in microbial ecosystems through horizontal gene transfer

Frontiers in Microbiology, 2016
The emergence and spread of antibiotic resistance among pathogenic bacteria has been a rising problem for public health in recent decades. It is becoming increasingly recognized that not only antibiotic resistance genes (ARGs) encountered in clinical ...
Christian Johannes Hendrik Von Wintersdorff, John ePenders, John ePenders, Julius M van Niekerk, Nathan Dominic Mills, Snehali eMajumder, Lieke B van Alphen, Paul HM Savelkoul, Paul HM Savelkoul, Paul HM Savelkoul, Petra FG Wolffs, Petra FG Wolffs   +11 more
doaj   +1 more source

Lipid-Based Nanomaterials for Drug Delivery Systems in Breast Cancer Therapy

Nanomaterials, 2022
Globally, breast cancer is one of the most prevalent diseases, inducing critical intimidation to human health. Lipid-based nanomaterials have been successfully demonstrated as drug carriers for breast cancer treatment.
Lekshmi Rethi, Chinmaya Mutalik, Dito Anurogo, Long-Sheng Lu, Hsiu-Yi Chu, Sibidou Yougbaré, Tsung-Rong Kuo, Tsai-Mu Cheng, Fu-Lun Chen   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results

Molecules, 2022
Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the ...
Hanggara Arifian, Rani Maharani, Sandra Megantara, Amirah Mohd Gazzali, Muchtaridi Muchtaridi   +4 more
doaj   +1 more source