Results 71 to 80 of about 285,333 (315)

CONJUGATIONS WITH GLUTATHIONE. THE ENZYMIC CONJUGATION OF SOME CHLOROCYCLOHEXENES [PDF]

Biochemical Journal, 1965
1. alpha-3,4,5,6-Tetrachlorocyclohex-1-ene and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene are conjugated with glutathione in vitro by a rat-liver enzyme that is probably glutathione S-aryltransferase. 2. Chlorocyclohexane and the alpha-, beta-, gamma- and delta-isomers of hexachlorocyclohexane were not substrates for rat-liver glutathione S ...
P, SIMS, P L, GROVER
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Insight into ortho-boronoaldehyde conjugation via a FRET-based reporter assay

, 2022
Ortho-boronoaldehydes react with amine-based nucleophiles with dramatically increased rates and product stabilities, relative to unfunctionalised benzaldehydes, leading to exciting applications across biological and material chemistry.
Anais, Sanchez, Nicholas, Rose, Eve, Tipple, Christopher, Spicer, Jason, Lynam   +4 more
core   +1 more source

The Conjugation Stress of Ligand via Metal Core as the Cause of Changes in the Reactivity of Coordinated 1-Hetero-1,3-Dienes [PDF]

Учёные записки Казанского университета: Серия Естественные науки, 2016
Using quantum-chemical calculations carried out for interpretation of the experimentally discovered reactivity of 1-hetero-1,3-dienes that are mono- and bidentally coordinated with the transition metal core, we have revealed that the difference in ...
A.I. Kuramshin, E.V. Kolpakova, R.A. Cherkasov, V.I. Galkin   +3 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Optical and digital phase conjugation techniques for fiber nonlinearity compensation [PDF]

, 2015
We discuss recent progress on the use of optical and digital phase conjugation techniques for nonlinearity compensation in optical fiber links. We compare the achievable performance gain of phase conjugated twin wave applied in two polarization states ...
McCarthy, M.E., M.E. McCarthy, Xu, T., Liga, G., Ellis, A.D., Lavery, D., D. Lavery, Le, S. T., P. Bayvel, Phillips, I., Turitsyn, S.K., Le, S.T., S. K. Turitsyn, Ellis, A. D., McCarthy, M. E., Turitsyn, S. K., T. Xu, Xu, Tianhua, I. Phillips, A.D. Ellis, S.T. Le, Bayvel, P.   +21 more
core   +1 more source

Linear conjugation problems [PDF]

, 2020
We investigate the linear conjugation problem for polyanalytic functions using function theory and Cauchy-type integrals. We explicitly construct a canonical matrix-function by using the recurrence procedure and use it to study the linear conjugation ...
Tran Quang Vuong
core   +1 more source

Retrovirus molecular conjugates [PDF]

Cellular and Molecular Life Sciences (CMLS), 2001
Retrovirus-derived vectors are currently the preferred vectors used for human gene therapy protocols. Serious safety concerns persist, however, which are specifically related to the formation of a replication-competent virus, and no synthesis method currently employed precludes its formation with certainty.
Q, Zhong, J K, Kolls, P, Schwarzenberger
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source