Results 11 to 20 of about 355,537 (249)

Exploring metabolism in scleroderma reveals opportunities for pharmacological intervention for therapy in fibrosis

Frontiers in Immunology, 2022
BackgroundRecent evidence has indicated that alterations in energy metabolism play a critical role in the pathogenesis of fibrotic diseases. Studies have suggested that ‘metabolic reprogramming’ involving the glycolysis and oxidative phosphorylation ...
Isabella Gomes Cantanhede, Isabella Gomes Cantanhede, Huan Liu, Huan Liu, Huan Liu, Vestaen Balbuena Rodriguez, Xu Shiwen, Voo H. Ong, Christopher P. Denton, Markella Ponticos, Guo Xiong, José Luiz Lima-Filho, David Abraham, Jeries Abu-Hanna, Jan-Willem Taanman   +14 more
doaj   +1 more source

Prospective assessment of cardiovascular risk parameters in patients with rheumatoid arthritis

Cardiovascular Ultrasound, 2018
Background The study presents a prospective follow-up assessment of cardiovascular (CV) risk parameters in patients with rheumatoid arthritis (RA) in comparison with control subjects. Methods The study group consisted of 41 RA patients.
Bożena Targońska-Stępniak, Mariusz Piotrowski, Robert Zwolak, Anna Drelich-Zbroja, Maria Majdan   +4 more
doaj   +1 more source

Microangiopathic antiphospholipid syndrome (MAPS) in the course of undifferentiated connective tissue disease

Journal of Medical Science, 2014
Introduction. The microangiopathic antiphospholipid syndrome (MAPS) is a subset of APS comprising those patients presenting with thrombotic microangiopathy and demonstrable antiphospholipid antibodies. Renal involvement occurs frequently in the course of
Bożena Targońska-Stępniak, Ewa Wielosz, Maria Majdan   +2 more
doaj   +1 more source

Neuro‐Sjögren: Uncommon or underestimated problem?

Brain and Behavior, 2020
Objectives Sjögren's syndrome (SS) is a chronic inflammatory disease with an autoimmune background with possible complications from peripheral (PNS) and central nervous system (CNS).
Marta Jaskólska, Magdalena Chylińska, Anna Masiak, Mariusz Siemiński, Marcin Ziętkiewicz, Zenobia Czuszyńska, Żaneta Smoleńska, Zbigniew Zdrojewski   +7 more
doaj   +1 more source

Viability of Periosteal Tissue Obtained Postmortem

Cell Transplantation, 1999
Periosteal autografts have the potential to regenerate articular cartilage defects, but this potential is limited by the patient's age. Allograft transplantation from a young donor to an older recipient might bypass this limitation.
Shawn W. O'driscoll Ph.D., M.D., Borna Meisami, Yasushi Miura, James S. Fitzsimmons   +3 more
doaj   +1 more source

Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling

Journal of Translational Medicine, 2018
Background Hepatocyte growth factor (HGF) plays a pivotal role in breast cancer cell motility, invasion and angiogenesis. These pro-metastatic events are triggered through HGF coupling and activation of the c-Met receptor.
Christian Parr, Ahmed Y. Ali
doaj   +1 more source

Usefulness in daily practice of the Systemic Lupus Erythematosus Disease Activity Index 2000 scale and the Systemic Lupus Erythematosus Disease Activity Score index for assessing the activity of systemic lupus erythematosus

Rheumatology
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by high hetero­geneity of clinical manifestations and an uncertain prognosis. Although the mortality rate due to SLE has decreased significantly in recent decades, there is still a
Dorota Suszek, Maciej Dubaj, Karol Bigosiński, Aleksandra Dembowska, Marcin Kaniewski, Wiktoria Sielwanowska, Bartosz Skierkowski, Izabela Dzikowska, Julia Sieczka, Maria Majdan   +9 more
doaj   +1 more source

Association study between immune-related miRNAs and mixed connective tissue disease

Arthritis Research & Therapy, 2021
Background Mixed connective tissue disease (MCTD) is a rare condition that is distinguished by the presence of specific U1-RNP antibodies. Information about its etiopathology and diagnostics is still unclear.
Barbara Stypińska, Aleksandra Lewandowska, Anna Felis-Giemza, Marzena Olesińska, Agnieszka Paradowska-Gorycka   +4 more
doaj   +1 more source

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source