Results 51 to 60 of about 598,756 (346)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Correlation of plasma interleukin-18 concentration and severity of renal involvement and disease activity in systemic lupus erythematosus [PDF]

Journal of Nephropathology, 2016
Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by activation of T and polyclonal B lymphocytes. IL-18 was originally identified as a factor which enhances IFN-γ production and is a potent inducer of the ...
Mohammad Reza Jafari-Nakhjavani, Sima Abedi-Azar, Babak Nejati   +2 more
doaj   +1 more source

Broadband hyperspectral imaging for breast tumor detection using spectral and spatial information [PDF]

, 2019
Complete tumor removal during breast-conserving surgery remains challenging due to the lack of optimal intraoperative margin assessment techniques. Here, we use hyperspectral imaging for tumor detection in fresh breast tissue.
Dashtbozorg, Behdad, de Boer, Lisanne L., Kho, Esther, Ruers, Theo J. M., Sterenborg, Henricus J. C. M., Van de Vijver, Koen   +5 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Challenging in leprosy relapse with antiphospholipid syndrome diagnosis: A case report

Clinical Case Reports
Key Clinical Message Infectious diseases like leprosy can cause antiphospholipid antibodies, leading to blood clots. Clinicians should consider this for patients with unusual thrombotic events and prior infectious disease history.
Sousan Kolahi, Leyla Ghadakchi, Amirreza Jabbaripour Sarmadian, Hamideh Azimi, Mehdi Jafarpour, Amirreza Khalaji   +5 more
doaj   +1 more source

Ocular involvement in rheumatic diseases

Rheumatology, 2023
Rheumatic diseases are associated with a significant decline in quality of life, which is not only related to the progression of the underlying disease but also to the development of coexisting conditions.
Iwona Dankiewicz- Fares, Daniel Jeka, Tacjana Barczyńska   +2 more
doaj   +1 more source

Arthrogryposis: A Rare Manifestation in Infant of Diabetic Mother [PDF]

, 2009
Arthrogryposis multiplex congenita is characterized by non-progressive, multiple joint contractures present at birth. The major cause of arthrogryposis is fetal akinesia due to fetal abnormalities like neurogenic, muscle, connective tissue abnormalities ...
Kumar, Arvind, Taksande, AM, Vilhekar, KY   +2 more
core  

A pseudo active kinematic constraint for a biological living soft tissue: an effect of the collagen network [PDF]

, 2008
Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber direction. We suggested
Bourdarias, Christian, Gerbi, Stéphane, Ohayon, Jacques   +2 more
core   +4 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Tumor localization in tissue microarrays using rotation invariant superpixel pyramids [PDF]

, 2015
Tumor localization is an important component of histopathology image analysis; it has yet to be reliably automated for breast cancer histopathology. This paper investigates the use of superpixel classification to localize tumor regions.
Akbar, Shazia, Jordan, Lee, McKenna, Stephen J., Thompson, Alastair M.   +3 more
core   +3 more sources