Results 61 to 70 of about 391,560 (313)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
, 2017 Aims Connective tissue growth factor (CTGF) is an emerging marker for tissue fibrosis. We investigated the association between CTGF and cardiac diastolic function using cellular and animal models and clinical human data Methods and results A total of ...
Wu, Cho-Kai;Wang, Yi-Chih;Lee, Jen-Kuang;Chang, Sheng-Nan;Su, Mao-Yuan;Yeh, Huei-Ming;Su, Ming-Jai;Chen, Jin-Jer;Chiang, Fu-Tien;Hwang, Juey-Jen;Lin, Jiunn-Lee;Tsai, Chia-Ti +1 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
'Connective Tissue,' 'Taxonomy'
, 2016 'Connective Tissue' won the 2015 Newcastle Poetry PrizeNo Full ...
Lawrence, Anthony
core
An acquired or heritable connective tissue disorder? a review of hypermobile Ehlers Danlos Syndrome [PDF]
, 2019 Hypermobile Ehlers Danlos Syndrome (hEDS) is a multifaceted disorder that is difficult to diagnose and manage primarily due to the unknown causes. Research on hEDS continues to evolve but tangible progress will be realized when the growing body of ...
Martin, A.
core +1 more source
The expression and methylation status of vitamin D receptor gene in Behcet's disease
Immunity, Inflammation and Disease, 2019 Introduction Vitamin D has important roles as a natural immune modulator via regulating the expression of genes which have been implicated in the pathophysiology of autoimmune diseases.
Sam Seydi Shirvani +7 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2011 A novel method for generating an antigen-specific cancer vaccine and immunotherapy has emerged using a DNA vaccine. However, antigen-presenting cells (APCs) have a limited life span, which hinders their long-term ability to prime antigen-specific T cells.
CHENG, WEN-FANG;CHANG, MING-CHENG;SUN, WEI-ZEN;LEE, CHIEN-NAN;LIN, HAN-WEI;SU, YI-NING;HSIEH, CHANG-YAO;CHEN, CHI-AN +1 more
core +1 more source
Comparison of the solophenyl-red polarization method and the immunohistochemical analysis for collagen type III [PDF]
, 1992 In the present study, we have compared the staining pattern of the Solophenyl-Red 3 BL-method for the visualization of collagen type III with the immunohistochemical staining in serial sections from 7 skin wounds (wound age 3 days up to 4 weeks) to ...
Penning, R. +5 more
core +1 more source