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Expression of connexin 43 in human testis
Histochemistry and Cell Biology, 1999In order to further characterize the Sertoli cell state of differentiation, we investigated the expression of connexin 43 (cx43) protein in the testis of adult men both with normal spermatogenesis and associated with spermatogenic impairment, since cx43 is first expressed during puberty.
K, Steger, F, Tetens, M, Bergmann
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Connexin 43 is localized with actin in tenocytes
Cell Motility, 2006AbstractVarieties of cell–matrix or cell–cell adhesions are associated with the actin cytoskeleton. However, for gap junctions, which are both channels and adhesions, there has been little evidence for such an association. The purpose of this study was to determine if connexin 43 (Cx43) associates with actin and to determine if this association is ...
Michelle E, Wall +3 more
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Connexin 43 in ischemic pre- and postconditioning
Heart Failure Reviews, 2007Connexin 43 (Cx43) is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium, but Cx43 is also localized at the inner membrane of cardiomyocyte mitochondria. In cardiomyocytes, Cx43 is involved in the formation of reactive oxygen species, which are central to the signal transduction cascade of ischemic ...
Rainer, Schulz +5 more
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Role of connexin 43 in cardiovascular diseases
European Journal of Pharmacology, 2015Gap junctions (GJs) channels provide the basis for intercellular communication in the cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular tone and endothelial function as well as metabolic interchange between the cells. They allow the transfer of small molecules and may enable slow calcium wave spreading, transfer
PECORARO, MICHELA +3 more
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American Journal of Physiology-Gastrointestinal and Liver Physiology, 1993
To determine the distribution of gap junction protein connexin 43 (Cx43) and the expression of Cx43 mRNA in different regions of canine small intestine and colon, modified Western blot and Northern blot techniques were used with a site-directed antibody raised against a synthetic peptide of Cx43 Anti-Cx43 (252-271) and a probe of 1.3-kb Cx43 cDNA ...
Z, Li, Z, Zhou, E E, Daniel
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To determine the distribution of gap junction protein connexin 43 (Cx43) and the expression of Cx43 mRNA in different regions of canine small intestine and colon, modified Western blot and Northern blot techniques were used with a site-directed antibody raised against a synthetic peptide of Cx43 Anti-Cx43 (252-271) and a probe of 1.3-kb Cx43 cDNA ...
Z, Li, Z, Zhou, E E, Daniel
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Posttranscriptional regulation of connexin-43 expression
Archives of Biochemistry and Biophysics, 2012Posttranscriptional regulation of the biosynthesis of connexins, the building blocks of gap junctional channels, may occur by modulation of connexin mRNA stability and translation. To date, few RNA binding proteins and micro-RNAs (miRNAs) affecting connexin expression are known.
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Remodeling of connexin 43 in the diabetic rat heart
Molecular and Cellular Biochemistry, 2006In the Streptozotocin-induced diabetic rat heart, a decrease in the conductivity and suppression of electrical cell-to-cell coupling were observed. To clarify this mechanism, the present study was performed to investigate alterations of the gap junction connexin 43 (Cx43) using immunoblotting, immunohistochemistry, electron-microscopic analyses.
Hai, Lin +3 more
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Bisphosphonates and Connexin 43: A Critical Review of Evidence
Cell Communication & Adhesion, 2014Bisphosphonates (BPs) are drugs commonly used in the treatment of various disease arising or affecting bone tissue. There is a standard use in bone neoplasia and metastasis, hormonal and developmental disorders as well as for compensation of adverse effects in several medical therapies.
Pooyan, Sadr-Eshkevari +6 more
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Expression of connexin-43 in human myometrium and leiomyoma
American Journal of Obstetrics and Gynecology, 1993The expression of connexin-43 was examined in human leiomyomas and in autologous myometrium.Indirect immunofluorescence was used to detect connexin-43 gap junctions in myometrial and leiomyoma tissues and in primary cultures. Immunoblot and Northern analyses were used to examine the levels of connexin-43 protein and cx43 messenger ribonucleic acid in ...
Peter R Brink +2 more
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The Emerging Role of Connexin 43 in Testis Pathogenesis
Current Molecular Medicine, 2013Direct intercellular communication is mediated by gap junctions and their constitutive proteins, the connexins, which are organized in a hexameric arrangement forming a channel between adjacent cells. Connexins are essential for cell homeostasis and are also involved in many physiological processes such as cell growth, differentiation and death ...
D, Chevallier +4 more
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