Results 151 to 160 of about 75,295 (332)
Diabetic Medicine, EarlyView.Abstract Aims Following an acute myocardial infarction (AMI), individuals with type 2 diabetes (T2DM) have a 2‐to‐3 fold increased risk of mortality compared to those without diabetes, and globally cardiorenal complications account for 50% of diabetes‐related deaths.
M. U. Shah +4 more
wiley +1 more source
Studies of intercellular Ca2+ signaling and gap-junction coupling in the developing cochlea of mouse models affected by congenital hearing loss [PDF]
, 2013 Connexin 26 (Cx26) and connexin 30 (Cx30) form gap junction channels that allow the intercellular diffusion of the Ca2+ mobilizing second messenger IP3.
Rodriguez Hernandez, Laura
core +1 more source
Connexin 40 promoter-based enrichment of embryonic stem cell-derived cardiovascular progenitor cells [PDF]
, 2008 Background: Pluripotent embryonic stem (ES) cells that can differentiate into functional cardiomyocytes as well as vascular cells in cell culture may open the door to cardiovascular cell transplantation.
David, R. +2 more
core +1 more source
Brain : a journal of neurology, 2014 Accumulating evidence suggests that spinal cord astrocytes play an important role in neuropathic pain sensitization by releasing astrocytic mediators (e.g. cytokines, chemokines and growth factors).
Gang Chen +5 more
semanticscholar +1 more source
Immunity and neuroinflammation in early stages of life and epilepsy
Epilepsia, EarlyView.Abstract The immune system is crucial for the correct brain development, and recent findings also point toward central control of immune response. As the immune system is not fully developed at birth, the early years become an important window for infections and for the development of epilepsy.
Angelica Vega García +5 more
wiley +1 more source
Endothelial connexins in vascular function
Vascular Biology, 2019 Gap junctions are essential for intercellular crosstalk in blood and lymphatic vasculature. These clusters of intercellular channels ensure direct communication among endothelial cells and between endothelial and smooth muscle cells, and the ...
Aurélie Hautefort +2 more
doaj +1 more source
A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel
The FEBS Journal, EarlyView.A truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Junjie Wang +5 more
wiley +1 more source
Journal of Biological Chemistry, 2015 Background: Connexin proteins form gap junction channel clusters termed plaques. Results: Microscopy with fluorescent protein-tagged connexins showed that connexin26 and connexin30 plaque arrangement is dynamic, but gap junctions of connexin43 are ...
Randy F. Stout, E. Snapp, D. Spray
semanticscholar +1 more source
Identification of a protein kinase activity that phosphorylates connexin43 in a pH-dependent manner
Brazilian Journal of Medical and Biological Research, 2000 The carboxyl-terminal (CT) domain of connexin43 (Cx43) has been implicated in both hormonal and pH-dependent gating of the gap junction channel. An in vitro assay was utilized to determine whether the acidification of cell extracts results in the ...
P. Yahuaca +4 more
doaj +1 more source
Journal of Cardiovascular Electrophysiology, EarlyView.ABSTRACT This state‐of‐the‐art review is based on the Philippe Coumel Lecture in 2024 (Figure 1). It highlights the confluence of two major cardiovascular epidemics, atrial fibrillation and heart failure, with preserved ejection fraction. In these conditions, advances in electrophysiology and heart failure physiology are intertwined and are integrated ...
Sanjeev Saksena +3 more
wiley +1 more source