Results 121 to 130 of about 1,008 (160)
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Molecular interaction of δ-conopeptide EVIA with voltage-gated Na(+) channels.
Biochimica et Biophysica Acta (BBA) - General Subjects, 2016Abstract Background For a large number of conopeptides basic knowledge related to structure-activity relationships is unavailable although such information is indispensable with respect to drug development and their use as drug leads. Methods A combined experimental and theoretical approach employing electrophysiology and molecular modeling was ...
D. Tietze +7 more
semanticscholar +3 more sources
Drugs from the Sea: Conopeptides as Potential Therapeutics
Current Medicinal Chemistry, 2004Marine cone snails from the genus Conus are estimated to consist of up to 700 species. These predatory molluscs have devised an efficient venom apparatus that allows them to successfully capture polychaete worms, other molluscs or in some cases fish as their primary food sources.
Bruce G, Livett +2 more
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Determination of disulfide bridge pattern in ω‐conopeptides
International Journal of Peptide and Protein Research, 1995Synthetic versions of seven naturally occurring ω‐conopeptides were subjected to structural analyses in order to determine their disulfide bridge pattern. The method applied in this study uses a combination of amino‐acid composition and peptide sequence analysis of various peptide fragments generated by different enzymatic digestions.
D, Chung +4 more
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Neuroscience
Glioblastoma (GBM) was identified as a highly aggressive and lethal primary brain tumor of the central nervous system, marked by significant inter- and intra-tumoral heterogeneity that limited therapeutic efficacy. This study aimed to target glioblastoma
Sandhanam Kuppusamy, Sumithra Mohan
semanticscholar +1 more source
Glioblastoma (GBM) was identified as a highly aggressive and lethal primary brain tumor of the central nervous system, marked by significant inter- and intra-tumoral heterogeneity that limited therapeutic efficacy. This study aimed to target glioblastoma
Sandhanam Kuppusamy, Sumithra Mohan
semanticscholar +1 more source
Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)
Current Topics in Medicinal Chemistry, 2012Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst < 0.1% have been pharmacologically characterised, those with known function typically target membrane proteins of therapeutic importance, including ion channels, transporters and GPCRs. Several conopeptides reduce pain in
Vetter, Irina, Lewis, Richard J.
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Conopeptide characterization and classifications: An analysis using ConoServer
Toxicon, 2010Cone snails are carnivorous marine gastropods that have evolved potent venoms to capture their prey. These venoms comprise a rich and diverse cocktail of peptide toxins, or conopeptides, whose high diversity has arisen from an efficient hypermutation mechanism, combined with a high frequency of post-translational modifications.
Kaas, Quentin +2 more
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Chemistry and Biodiversity
Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor with limited effective treatments. This study explores the anti‐GBM potential of an α‐conopeptide isolated from the venom of Conus planorbis, a marine cone snail from Rameswaram ...
Sandhanam Kuppusamy, Sumithra Mohan
semanticscholar +1 more source
Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor with limited effective treatments. This study explores the anti‐GBM potential of an α‐conopeptide isolated from the venom of Conus planorbis, a marine cone snail from Rameswaram ...
Sandhanam Kuppusamy, Sumithra Mohan
semanticscholar +1 more source
Post-translationally modified conopeptides: Biological activities and pharmacological applications
Peptides, 2021Conus venoms comprise a large variety of biologically active peptides (conopeptides or conotoxins) that are employed for prey capture and other biological functions. Throughout the course of evolution of the cone snails, they have developed an envenomation scheme that necessitates a potent mixture of peptides, most of which are highly post ...
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Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB-1.
British Journal of PharmacologyBACKGROUND AND PURPOSE Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore.
Sujin Lim +10 more
semanticscholar +1 more source
Synthesis and insecticidal activity of cysteine-free conopeptides from Conus betulinus
Toxicon, 2023The cone snail Conus betulinus is a vermivorous species that is widely distributed in the South China Sea. Its crude venom contains various peptides used to prey on marine worms. In previous studies, a systematic analysis of the peptide toxin sequences from C. betulinus was carried out using a multiomics technique.
Jiao, Chen +3 more
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