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Conopeptide characterization and classifications: An analysis using ConoServer
Toxicon, 2010Cone snails are carnivorous marine gastropods that have evolved potent venoms to capture their prey. These venoms comprise a rich and diverse cocktail of peptide toxins, or conopeptides, whose high diversity has arisen from an efficient hypermutation mechanism, combined with a high frequency of post-translational modifications.
Quentin K Kaas, David Craik
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Therapeutic Potential of Conopeptides
Future Medicinal Chemistry, 2012Conopeptides from the venoms of marine snails have attracted much interest as leads in drug design. Currently, one drug, Prialt(®), is on the market as a treatment for chronic neuropathic pain. Conopeptides target a range of ion channels, receptors and transporters, and are typically small, relatively stable peptides that are generally amenable to ...
Schroeder, Christina I., Craik, David J.
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Conopeptides: From deadly venoms to novel therapeutics
Drug Discovery Today, 2000Marine cone snails have developed many distinct venoms that contain biologically active peptides as part of an envenomation survival strategy for feeding and defense. These peptides, known as conopeptides, have been optimized through evolution to target specific ion channels and receptors with very high affinities and selectivities.
, Shen, , Layer, , McCabe
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Drugs from Slugs. Part II – Conopeptide bioengineering
Chemico-Biological Interactions, 2012The biological transformation of toxins as research probes, or as pharmaceutical drug leads, is an onerous and drawn out process. Issues regarding changes to pharmacological specificity, desired potency, and bioavailability are compounded naturally by their inherent toxicity.
Jon-Paul, Bingham +3 more
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Drugs from the Sea: Conopeptides as Potential Therapeutics
Current Medicinal Chemistry, 2004Marine cone snails from the genus Conus are estimated to consist of up to 700 species. These predatory molluscs have devised an efficient venom apparatus that allows them to successfully capture polychaete worms, other molluscs or in some cases fish as their primary food sources.
Bruce G, Livett +2 more
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Determination of disulfide bridge pattern in ω‐conopeptides
International Journal of Peptide and Protein Research, 1995Synthetic versions of seven naturally occurring ω‐conopeptides were subjected to structural analyses in order to determine their disulfide bridge pattern. The method applied in this study uses a combination of amino‐acid composition and peptide sequence analysis of various peptide fragments generated by different enzymatic digestions.
D, Chung +4 more
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Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)
Current Topics in Medicinal Chemistry, 2012Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst < 0.1% have been pharmacologically characterised, those with known function typically target membrane proteins of therapeutic importance, including ion channels, transporters and GPCRs. Several conopeptides reduce pain in
Vetter, Irina, Lewis, Richard J.
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Post-translationally modified conopeptides: Biological activities and pharmacological applications
Peptides, 2021Conus venoms comprise a large variety of biologically active peptides (conopeptides or conotoxins) that are employed for prey capture and other biological functions. Throughout the course of evolution of the cone snails, they have developed an envenomation scheme that necessitates a potent mixture of peptides, most of which are highly post ...
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Synthesis and insecticidal activity of cysteine-free conopeptides from Conus betulinus
Toxicon, 2023The cone snail Conus betulinus is a vermivorous species that is widely distributed in the South China Sea. Its crude venom contains various peptides used to prey on marine worms. In previous studies, a systematic analysis of the peptide toxin sequences from C. betulinus was carried out using a multiomics technique.
Jiao, Chen +3 more
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