Results 121 to 130 of about 771 (173)

Putative α7-selective ligands interact with α9-containing nicotinic acetylcholine receptors and modulate immune functions of human mononuclear phagocytes. [PDF]

Front Immunol
Mobasher M, Hone AJ, Pilzecker M, Bozic D, Hecker A, McIntosh JM, Kirschner KN, Grau V, Papke RL, Andleeb H, Richter K.   +10 more
europepmc   +1 more source

Multifaceted Marine Peptides and Their Therapeutic Potential. [PDF]

Mar Drugs
Guryanova SV, Ovchinnikova TV.
europepmc   +1 more source

Effects of Selenomethionine Supplementation on Tomato Fruit Quality and Yield Under Deficit Irrigation. [PDF]

Int J Mol Sci
Gao Y, Chen J, Xie L, Liang H, Wang B, Liu N, Li N, Liu M, Ji Y.   +8 more
europepmc   +1 more source

Human α10 nicotinic acetylcholine receptor subunits assemble to form functional receptors. [PDF]

J Biol Chem
Tekarli B, Azam L, Hone AJ, McIntosh JM.
europepmc   +1 more source

Conopeptide characterization and classifications: An analysis using ConoServer

Toxicon, 2010
Cone snails are carnivorous marine gastropods that have evolved potent venoms to capture their prey. These venoms comprise a rich and diverse cocktail of peptide toxins, or conopeptides, whose high diversity has arisen from an efficient hypermutation mechanism, combined with a high frequency of post-translational modifications.
Quentin Kaas, David Craik
exaly   +7 more sources

Overexpression, purification, and pharmacological activity of a biosynthetically derived conopeptide [PDF]

Biochemical and Biophysical Research Communications, 2005
A high yielding fusion protein system based on the protein cytochrome b(5) has been used for the production of novel 13-residue acyclic conopeptide. This peptide, Mo1659, can be liberated from the carrier protein using CNBr cleavage and subsequent purification using RP-HPLC methods. The yield of isotopically enriched peptides is high, ranging from 3 to
Siddhartha P Sarma, Sujit Kumar Sikdar
exaly   +6 more sources

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Therapeutic Potential of Conopeptides

Future Medicinal Chemistry, 2012
Conopeptides from the venoms of marine snails have attracted much interest as leads in drug design. Currently, one drug, Prialt(®), is on the market as a treatment for chronic neuropathic pain. Conopeptides target a range of ion channels, receptors and transporters, and are typically small, relatively stable peptides that are generally amenable to ...
Schroeder, Christina I., Craik, David J.
openaire   +5 more sources

Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium-channel antagonist, SNX-230 (ω-conopeptide MVIIC)

Brain Research, 1994
Neuronal voltage-sensitive calcium channels (VSCCs) are a diverse family of proteins that regulate entry of Ca2+ into neurons. Selective antagonists of VSCCs have proven to be powerful pharmacological tools for identifying and characterizing these ...
Kishorchandra Gohil, G P Miljanich, George P Miljanich   +2 more
exaly   +2 more sources

A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

British Journal of Pharmacology, 2012
BACKGROUND AND PURPOSE The µ-conopeptide family is defined by its ability to block voltage-gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics.
Evelyne Benoit, Stefan H. Heinemann
exaly   +1 more source