Results 131 to 140 of about 771 (173)
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Stereochemistry of 4-hydroxyproline affects the conformation of conopeptides
Chemical Communications, 2010The cis/trans isomerization of 4-hydroxyproline is shown to remarkably affect the conformation of conopeptides with or without disulfide bonds.
Jia, Xu +4 more
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Determination of disulfide bridge pattern in ω‐conopeptides
International Journal of Peptide and Protein Research, 1995Synthetic versions of seven naturally occurring ω‐conopeptides were subjected to structural analyses in order to determine their disulfide bridge pattern. The method applied in this study uses a combination of amino‐acid composition and peptide sequence analysis of various peptide fragments generated by different enzymatic digestions.
D, Chung +4 more
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Conopeptides: From deadly venoms to novel therapeutics
Drug Discovery Today, 2000Marine cone snails have developed many distinct venoms that contain biologically active peptides as part of an envenomation survival strategy for feeding and defense. These peptides, known as conopeptides, have been optimized through evolution to target specific ion channels and receptors with very high affinities and selectivities.
, Shen, , Layer, , McCabe
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Drugs from the Sea: Conopeptides as Potential Therapeutics
Current Medicinal Chemistry, 2004Marine cone snails from the genus Conus are estimated to consist of up to 700 species. These predatory molluscs have devised an efficient venom apparatus that allows them to successfully capture polychaete worms, other molluscs or in some cases fish as their primary food sources.
Bruce G, Livett +2 more
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Novel conopeptides in a form of disulfide-crosslinked dimer
Peptides, 2010In our present work, seven conotoxins and conopeptides were cloned from four cone snail species based on the M-superfamily signal peptides. Among them, two conopeptides, Vt3.1 and Vt3.2, showed unusual sequence characteristics. Both of them contained two cysteines that are separated by just one non-cysteine residue. In vitro, the chemically synthesized
Xue-Chen, Wu +5 more
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Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)
Current Topics in Medicinal Chemistry, 2012Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst < 0.1% have been pharmacologically characterised, those with known function typically target membrane proteins of therapeutic importance, including ion channels, transporters and GPCRs. Several conopeptides reduce pain in
Vetter, Irina, Lewis, Richard J.
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Cardiovascular Effects of ω-Conopeptides in Conscious Rats: Mechanisms of Action
Journal of Cardiovascular Pharmacology, 1992We examined the effects of omega-conopeptides, a novel class of neuronal voltage-gated calcium channel antagonists, on hemodynamic responses in rats. Intravenous (i.v.) injections of SNX-111 (omega-conopeptide MVIIA) dose-dependently decreased arterial blood pressure (BP) in conscious rats. Intracerebroventricular (i.c.v.) SNX-111 injections (580 pmol)
S. Scott Bowersox +5 more
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Conotoxins and other conopeptides
2014Conopeptides are a large family of peptide toxins produced by marine cone snails. They act with high potency and exquisite specificity on a range of ion channels and transporters of the nervous system, making them valuable drug leads and important molecular probes in neurophysiological studies.
Kaas, Quentin, Craik, David J.
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Drugs from Slugs. Part II – Conopeptide bioengineering
Chemico-Biological Interactions, 2012The biological transformation of toxins as research probes, or as pharmaceutical drug leads, is an onerous and drawn out process. Issues regarding changes to pharmacological specificity, desired potency, and bioavailability are compounded naturally by their inherent toxicity.
Jon-Paul, Bingham +3 more
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DISCOVERY AND CHARACTERISATION OF CONOPEPTIDE ANTAGONISTS OF NICOTINIC ACETYLCHOLINE RECEPTORS
2023Neuronal nicotinic acetylcholine receptors (nAChRs) are of crucial physiological importance and they have also been implicated in a number of pathological conditions thus representing important targets for pharmacological intervention. Knowledge of the structure-function relationships of receptor: ligand interactions can facilitate design of improved ...
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