Results 161 to 170 of about 1,087 (186)

Structure-aided function assignment to the transcriptomic conopeptide Am931

Toxicon
Implementation of the next-generation technologies for gene sequencing of venom duct transcriptome has provided a large number of peptide sequences of marine cone snails. Emerging technologies on computational platforms are now rapidly evolving for the accurate predictions of the 3D structure of the polypeptide using the primary sequence.
Shamasoddin, Shekh, Shweta, Dhannura, Pooja, Dhurjad, Challa, Ravali, Spoorti, M M, Sreepriya, Kakkat, , Vishwajyothi, Marimuthu, Vijayasarathy, Rajesh, Sonti, Konkallu Hanumae, Gowd   +9 more
openaire   +2 more sources

Two short d-Phe-containing cysteine-free conopeptides from Conus marmoreus

Peptides, 2010
The cysteine-free conopeptides are naturally occurring components of the venom of cone snails and have been relatively less investigated than the cysteine-containing conopeptides. In this work, we used thiol-exchange chromatography to isolate cysteine-free conopeptides from the venom of Conus marmoreus.
Ling, Zhang, Xiaoxia, Shao, Chengwu, Chi, Chunguang, Wang   +3 more
openaire   +2 more sources

Subtype-specific block of voltage-gated K+ channels by μ-conopeptides

Biochemical and Biophysical Research Communications, 2017
The neurotoxic cone snail peptide μ-GIIIA specifically blocks skeletal muscle voltage-gated sodium (NaV1.4) channels. The related conopeptides μ-PIIIA and μ-SIIIA, however, exhibit a wider activity spectrum by also inhibiting the neuronal NaV channels NaV1.2 and NaV1.7.
Enrico Leipold, Florian Ullrich, Markus Thiele, Alesia A. Tietze, Heinrich Terlau, Diana Imhof, Stefan H. Heinemann   +6 more
openaire   +2 more sources

Direct cDNA cloning of novel conopeptide precursors of the O-superfamily

Peptides, 2005
Conotoxins from the venom of marine cone snails (genus Conus) represent large families of proteins exhibiting a similar precursor organization, but highly diverse pharmacological activities. A directed PCR-based approach using primers according to the conserved signal sequence was applied to investigate the diversity of conotoxins from the O ...
Silke, Kauferstein, Christian, Melaun, Dietrich, Mebs   +2 more
openaire   +2 more sources

Discovery and development of the χ-conopeptide class of analgesic peptides

Toxicon, 2012
Cone snail venoms continue to provide a rich source of bioactive peptides useful as research tools and leads to new therapeutics. We isolated two closely related conopeptides, MrIA and MrIB, which defined the χ-conopeptide class of bioactive peptides based on their unique ability to highly selectively and non-competitively inhibit the norepinephrine ...
openaire   +3 more sources

Comment on Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl-d-Aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro

ACS Nano, 2021
Elena A Molokanova, Gary B Braun
exaly  

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

Nucleic Acids Research, 2012
Quentin K Kaas, Rilei Yu, Ai-Hua Jin
exaly  

Im10A, a short conopeptide isolated from Conus imperialis and possesses two highly concentrated disulfide bridges and analgesic activity

Peptides, 2016
Ling Jiang, Qiuyun Dai
exaly  

Solution Structure of Conomarphin, a Novel Conopeptide Containing D-Amino Acid at pH 5

Acta Physico-chimica Sinica, 2008
Weihong Du
exaly  

Position-specific scoring matrix and hidden Markov model complement each other for the prediction of conopeptide superfamilies

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2013
Maido Remm, Frederique Lisacek
exaly