Results 141 to 150 of about 1,008 (160)

Subtype-specific block of voltage-gated K+ channels by μ-conopeptides

Biochemical and Biophysical Research Communications, 2017
The neurotoxic cone snail peptide μ-GIIIA specifically blocks skeletal muscle voltage-gated sodium (NaV1.4) channels. The related conopeptides μ-PIIIA and μ-SIIIA, however, exhibit a wider activity spectrum by also inhibiting the neuronal NaV channels NaV1.2 and NaV1.7.
Enrico Leipold, Florian Ullrich, Markus Thiele, Alesia A. Tietze, Heinrich Terlau, Diana Imhof, Stefan H. Heinemann   +6 more
openaire   +2 more sources

Direct cDNA cloning of novel conopeptide precursors of the O-superfamily

Peptides, 2005
Conotoxins from the venom of marine cone snails (genus Conus) represent large families of proteins exhibiting a similar precursor organization, but highly diverse pharmacological activities. A directed PCR-based approach using primers according to the conserved signal sequence was applied to investigate the diversity of conotoxins from the O ...
Silke, Kauferstein, Christian, Melaun, Dietrich, Mebs   +2 more
openaire   +2 more sources

Comment on Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl-d-Aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro

ACS Nano, 2021
E. Molokanova, G. Braun
semanticscholar   +1 more source

Reply to Comment on Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl-d-aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro.

ACS Nano, 2021
P. Valente, D. Kiryushko, Silvio Sacchetti, P. Machado, C. Cobley, V. Mangini, A. Porter, Joachim P. Spatz, R. Fleck, F. Benfenati, R. Fiammengo   +10 more
semanticscholar   +1 more source

Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor

Acta Pharmaceutica Sinica B
Jinghui Zhang, Zhengji Yin, Yue Li, Cheng Ge, Zixuan Zhang, Pu Yuan, Tao Jiang, D. Craik, Yan Zhao, Rilei Yu   +9 more
semanticscholar   +1 more source

A New, High Yield, Rapid, and Cost‐Effective Protocol to Deprotection of Cysteine‐Rich Conopeptide, Omega‐Conotoxin MVIIA

Chemical Biology and Drug Design, 2016
Seyed Sahand Eisapoor, S. Jamili, D. Shahbazzadeh, P. Ghavam Mostafavi, K. Pooshang Bagheri   +4 more
semanticscholar   +1 more source

Contryphan‐Bt: A pyroglutamic acid containing conopeptide isolated from the venom of Conus betulinus

Toxicon, 2017
Penggang Han, Ying Cao, Shangyi Liu, Xiandong Dai, G. Yao, C. Fan, Wenjian Wu, Jisheng Chen   +7 more
semanticscholar   +1 more source

Im10A, a short conopeptide isolated from Conus imperialis and possesses two highly concentrated disulfide bridges and analgesic activity.

Peptides, 2016
Shuo Yu, Tianpeng Du, Zhuguo Liu, Qiaoling Wu, Guixue Feng, Mingxin Dong, Xiaowei Zhou, Lingfa Jiang, Qiuyun Dai   +8 more
semanticscholar   +1 more source

Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome

Zeitschrift für Induktive Abstammungs- und Vererbungslehre, 2015
Neda Barghi, G. Concepcion, B. Olivera, A. Lluisma   +3 more
semanticscholar   +1 more source

Effects of conopeptide-containing venom from seven species of Conidae gastropoda on the chick biventer-cervicis nerve-muscle assessed using the ConoServer database.

International journal of clinical pharmacology and therapeutics, 2016
E. Brown, E. L. Masinde, B. Woodcock
semanticscholar   +1 more source