Results 201 to 210 of about 588,087 (304)

CRISPR/Cas13a: Compensatory Target Activation Mechanism

Advanced Science, EarlyView.
CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang, Tenghua Zhang, Yao Lu, Shujun Zhou, Wenjing Xiao, Shuming Pan, Nan Shi, Yan Sheng, Jiaming Hu   +8 more
wiley   +1 more source

Exploring the causes of learning burnout in online learning among master's students: a Q-methodology study. [PDF]

Front Psychol
Zuo S, Li Y, Li J, Zhu X, Liu N, Wang JB.   +5 more
europepmc   +1 more source

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source

Anxiety sensitivity and occupational fatigue in meteorological exploration personnel: a serial mediation model of recovery experience and emotion regulation self-efficacy. [PDF]

Front Psychol
Ji X, Yang Y, Xu Y, Zuo Y, Wang M.
europepmc   +1 more source

Artificial Intelligence Powers Protein Functional Annotation

Advanced Science, EarlyView.
This review systematically summarizes how artificial intelligence advances protein functional annotation. It organizes existing methods into six unified modeling paradigms and analyzes their applications in Gene Ontology and Enzyme Commission prediction.
Wenkang Wang, Qiurong Yang, Min Zeng, Ruiqing Zheng, Min Li   +4 more
wiley   +1 more source

Diverse Landscape of Tunable Magnetic, Topological, and Ferroelectric States in 2D Ti3Se3Te2

Advanced Science, EarlyView.
Ti3Se3Te2 emerges as a multifunctional 2D van der Waals platform. The monolayer is a dynamically stable ferromagnetic quantum anomalous Hall insulator. In bilayers, two stacking configurations yield distinct phases: AA‐stacking hosts an altermagnetic quantum spin Hall insulator, while AA′‐stacking exhibits three‐state in‐plane ferroelectricity ...
Jiangtao Yu, Jingbo Bai, Yali Yang, Shifeng Qian, Xiaotian Wang, Zhuhong Liu   +5 more
wiley   +1 more source

The impact of career adapt-abilities on AI anxiety among English majors: a dual perspective analysis based on core self-evaluations at the person- and variable-centered. [PDF]

Front Psychol
Wang X.
europepmc   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

A study on the relationship between digital leadership, digital self-efficacy, and work engagement: the moderating role of technostress. [PDF]

Front Psychol
Li J, Wang Y, Han J.
europepmc   +1 more source

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source