Results 91 to 100 of about 530,710 (287)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Analysis of dependencies in low frequency financial data sets [PDF]

open access: yes
This empirical study proposes a dependency analysis of monthly financial time series. We use the overlapping technique and non-parametric correlation in order to increase both accuracy and consistency.
Ardia, David
core   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Joint Object Detection and Multi-Object Tracking Based on Hypergraph Matching

open access: yesApplied Sciences
Addressing the challenges in online multi-object tracking algorithms under complex scenarios, where the independence among feature extraction, object detection, and data association modules leads to both error accumulation and the difficulty of ...
Zhoujuan Cui   +3 more
doaj   +1 more source

Lexicographic Compositions of Two Criteria for Decision Making [PDF]

open access: yes
This paper considers two distinct procedures to lexicographically compose two criteria for social or individual decision making. The first procedure composes two binary relations into one, and then selects its maximal elements. The second procedure first
Houy, Nicolas, Tadenuma, Koichi
core  

Pre- and Postintervention Factor Structure of Functional Independence Measure in Patients with Spinal Cord Injury

open access: yesRehabilitation Research and Practice, 2017
Objective To evaluate the factor structure of Functional Independence Measure (FIM®) scale amongst people with spinal cord injury (SCI). Methods This was a retrospective, register-based cohort study on 155 rehabilitants with SCI.
M. Saltychev   +3 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Development and validation of an Age-related Language Decline Scale (ALDS) for older adults

open access: yesActa Psychologica
Objectives: Language decline in older adults poses a great threat to their independence. A self-report scale designed to measure age-related language decline could be very efficient, but it is still lacking.
Xinan Zhou, Yanping Dong
doaj   +1 more source

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