Results 81 to 90 of about 82,488 (269)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Inference on semiparametric models with discrete regressors [PDF]

, 1993
We study statistical properties of coefficient estimates of the partially linear regression model when some or all regressors, in the unknown part of the model, are discrete. The method does not require smoothing in the discrete variables.
Delgado, Miguel A., Miguel A. Delgado, Juan Morao, Mora, Juan   +3 more
core  

Psychometric performance of the WHOQOL-HIV BREF among people living with HIV on antiretroviral therapy in Bauchi State, Nigeria.

PLoS ONE
BackgroundThe well-being of people living with HIV (PLHIV) remains a significant public health concern. Despite advancements in ART, PLHIV face various challenges impacting their quality of life (QOL).
Ekerette Emmanuel Udoh, Adesola Zaidat Musa, Tubosun Alex Olowolafe, Taiwao Mofadeke Jaiyeola   +3 more
doaj   +1 more source

Quality assessment of clinical practice guidelines and consensuses for fungal diseases in China from 2023 to 2024: a study based on the AGREEⅡ

Guangxi Yike Daxue xuebao
Objective To systematically assess the methodological quality of clinical practice guidelines for fungal diseases to provide a reference for the formulation of guidelines/consensuses in the field of fungal diseases in the future.
Xiaopan WANG, Mengya SHANG, Wenjie FANG, Mingwei DU, Xinlin ZHU, Qi YIN, Xiaogang LIU, Weihua PAN, Yinuo LIU, Wanqing LIAO   +9 more
doaj   +1 more source

High fat diet results in ovarian gene dysregulation independent of obesity: RNA sequencing reveals expression changes consistent with de novo inflammation and apoptosis [PDF]

Fertility and Sterility, 2017
N.M. Hohos, K. Cho, D. Swindle, A.J. Polotsky, M.E. Skaznik-Wikiel   +4 more
openaire   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Convergent Observational Pressure on ΛCDM: Eight Independent Results Consistent with Quantum-Geometry Dynamics

Standard cosmology based on ΛCDM faces a convergent crisis from multiple independent observational results published in 2024–2026. This paper documents eight distinct empirical findings — each in tension with ΛCDM predictions — and demonstrates that each is consistent with, and in several cases predicted by, the ...
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source