Results 91 to 100 of about 543,710 (291)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Psychometric Properties of the Make My Day Tool to Assess Perceived Performance of Children ’ s Daily Activities

open access: yesOpen Journal of Occupational Therapy, 2017
Background: No instrument with strong psychometric qualities exists to measure occupational performance in young children through child-reporting. We investigated the reliability and validity of the Make My Day (MMD) tool for children aged 4 to 7 years
Liron Or, Tsameret Ricon
doaj   +1 more source

A pooling approach to judgment aggregation [PDF]

open access: yes, 2012
The literature has focused on a particular way of aggregating judgments: Given a set of yes or no questions or issues, the individuals’ judgments are then aggregated separately, issue by issue.
García-Bermejo Ochoa, Juan Carlos
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Numerical study of the discharge properties of atmospheric dielectric barrier discharge by using 200 kHz/13.56 MHz excitations

open access: yesAIP Advances, 2018
In this work involving an atmospheric dielectric barrier discharge system, the feasibility of independence control of key plasma parameters through strategic modulation of applied dual-frequency excitation sources is demonstrated.
F. R. Kong, Z. L. Zhang, B. H. Jiang
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Quality assessment of clinical practice guidelines and consensuses for fungal diseases in China from 2023 to 2024: a study based on the AGREEⅡ

open access: yesGuangxi Yike Daxue xuebao
Objective To systematically assess the methodological quality of clinical practice guidelines for fungal diseases to provide a reference for the formulation of guidelines/consensuses in the field of fungal diseases in the future.
Xiaopan WANG   +9 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Measurement Validity of the Low Vision Independence Measure (LVIM).

open access: yesAmerican Journal of Occupational Therapy, 2019
OBJECTIVE This study's objective was to test the psychometrics of Smith's (2013) Low Vision Independence Measure (LVIM) using the Rasch model. METHOD A cohort design was used with 93 participants receiving occupational therapy for low vision ...
Theresa M. Smith   +3 more
semanticscholar   +1 more source

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