Results 91 to 100 of about 92,286 (267)
Hierarchical composite endpoints in clinical trials for multimorbid older adults
EClinicalMedicineSummary: Hierarchical composite endpoints (HCEs) has the potential to make clinical trials for multimorbid older adults more relevant. Unlike conventional time-to-first-event analyses—which can give more weight to outcomes of lesser relevance—HCEs rank ...
Priya Vart
doaj +1 more source
A consistency test of the time trade-off [PDF]
This paper tests the internal consistency of time trade-off utilities. We find significant violations of consistency in the direction predicted by loss aversion. The violations disappear for higher gauge durations.
José Luis Pinto +2 more
core
Implementation of Independence Character Education in Madrasah [PDF]
, 2022 This study aims to explore information related to the implementation of self-reliance character education through the creation of a school climate in Madrasah Tsanawiyah Dayah Darul Huda, Langsa City.
Desy, Desy +4 more
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Development and validation of an Age-related Language Decline Scale (ALDS) for older adults
Acta PsychologicaObjectives: Language decline in older adults poses a great threat to their independence. A self-report scale designed to measure age-related language decline could be very efficient, but it is still lacking.
Xinan Zhou, Yanping Dong
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Evaluation of a solidary academic-pedagogical project in virtual graduate programs
Frontiers in EducationThe consolidation of virtual education as a strategic modality in postgraduate training requires rigorous evaluations of its relevance from the student perspective.
Kris Evelin Ortiz-Ordoñez +2 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source