Results 101 to 110 of about 530,710 (287)

Inconsistencies in Reported Employment Characteristics among Employed Stayers [PDF]

The paper deals with measurement error, and its potentially distorting role, in information on industry and professional status collected by labour force surveys.
Bassi, Francesca, Padoan, Alessandra, Trivellato, Ugo   +2 more
core  

Tumour thrombus consistency has no impact on survival in patients with renal cell carcinoma.

Polish journal of pathology : official journal of the Polish Society of Pathologists, 2016
The prognosis of renal cell carcinoma (RCC) with venous tumour thrombus (VTT) is variable and not always possible to predict. The prognostic impact and independence of tumour thrombus-related factors including the recently introduced tumour thrombus ...
T. Golabek, M. Przydacz, K. Okoń, J. Kopczyński, J. Bukowczan, R. Sobczyński, Ł. Curyło, K. Gołąbek, P. Chłosta   +8 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Hierarchical composite endpoints in clinical trials for multimorbid older adults

EClinicalMedicine
Summary: Hierarchical composite endpoints (HCEs) has the potential to make clinical trials for multimorbid older adults more relevant. Unlike conventional time-to-first-event analyses—which can give more weight to outcomes of lesser relevance—HCEs rank ...
Priya Vart
doaj   +1 more source

Quality of life among HIV-tuberculosis co-infected patients

Perspectives in Clinical Research, 2019
Background: India is the world's third leading country in terms of people living with human deficiency virus (HIV) (2.1 million) with 0.4 million deaths due to HIV-associated tuberculosis (TB). Physical and mental stress degrades the quality of life (QOL)
Dharmendra Kumar Jha, Jyotsna Jha, Anshu Kumar Jha, Basavaprabhu Achappa, Ramesh Holla   +4 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The cost efficiency of German banks: a comparison of SFA and DEA [PDF]

We investigate the consistency of efficiency scores derived with two competing frontier methods in the financial economics literature: Stochastic Frontier and Data Envelopment Analysis.
Fiorentino, Elisabetta, Karmann, Alexander, Koetter, Michael   +2 more
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Evaluation of a solidary academic-pedagogical project in virtual graduate programs

Frontiers in Education
The consolidation of virtual education as a strategic modality in postgraduate training requires rigorous evaluations of its relevance from the student perspective.
Kris Evelin Ortiz-Ordoñez, Diana Carolina Burbano-Gonzalez, Jorge Andrés Suarez-Muñoz   +2 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source