Results 181 to 190 of about 45,599 (229)
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An update on the constitutive androstane receptor (CAR)
dmdi, 2013Abstract The constitutive androstane receptor (CAR; NR1I3) has emerged as one of the main drug- and xenobiotic-sensitive transcriptional regulators. It has a major effect on the expression of several oxidative and conjugative enzymes and transporters, and hence, CAR can contribute to drug/drug interactions.
Ferdinand, Molnár +4 more
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Pharmacogenetics of the Constitutive Androstane Receptor
Pharmacogenomics, 2007The constitutive androstane receptor (CAR), a member of the NR1I group of nuclear hormone receptors, has been implicated in regulating the expression of genes that are critical in xenobiotic and endobiotic metabolism, uptake and elimination as well as genes involved in various other physiological processes. Hence, functional variation in CAR associated
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Polyphenols in Alcoholic Beverages Activating Constitutive Androstane Receptor CAR
Bioscience, Biotechnology, and Biochemistry, 2011The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins. We examined alcoholic beverage phytochemicals for their ability to activate CAR. HepG2 cells were transfected with CAR expression vector and its reporter gene, and then treated with trans-resveratrol,
Ruiqing, Yao +9 more
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Isolation and characterization of Schistosoma mansoni constitutive androstane receptor
Molecular and Biochemical Parasitology, 2006Full length cDNA clones encoding a Schistosoma mansoni homologue of vertebrate CAR/PXR/VDR group nuclear receptor, termed SmCAR were isolated from screening a S. mansoni adult worm cDNA library. SmCAR is a 702 amino acid protein which retains a typical domain organization of nuclear receptor superfamily members.
Rong, Hu +3 more
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Биохимия, 2023
Constitutive androstane receptor (CAR, NR1I3) activation by chemical compounds evokes liver hyperplasia in rodent. 1,4-Bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP), a mouse CAR agonist, is most commonly used to study chemically induced liver hyperplasia and hepatocyte proliferation in vivo.
Mark E, Mazin +7 more
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Constitutive androstane receptor (CAR, NR1I3) activation by chemical compounds evokes liver hyperplasia in rodent. 1,4-Bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP), a mouse CAR agonist, is most commonly used to study chemically induced liver hyperplasia and hepatocyte proliferation in vivo.
Mark E, Mazin +7 more
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Constitutive androstane receptor activation evokes the expression of glycolytic genes
Biochemical and Biophysical Research Communications, 2016It is well-known that constitutive androstane receptor (CAR) activation by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) increases the liver-to-body weight ratio. CAR-mediated liver growth is correlated with increased expression of the pleiotropic transcription factor cMyc, which stimulates cell cycle regulatory genes and drives proliferating ...
Andrei A. Yarushkin +5 more
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High-Content Analysis of Constitutive Androstane Receptor Nuclear Translocation
2019The constitutive androstane receptor (CAR; NR1I3) is a xenobiotic receptor that upregulates metabolism and detoxification mechanisms in the liver in response to chemical stimulation. Drug-induced activation of CAR may result in clinically significant drug-drug interactions and lead to complicated therapeutic outcomes.
Bryan, Mackowiak, Hongbing, Wang
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Constitutive androstane receptor–vitamin D receptor crosstalk: Consequence on CYP24 gene expression
Biochemical and Biophysical Research Communications, 2007We previously reported that the pregnane X receptor (PXR) interferes with vitamin D receptor (VDR) target genes, notably CYP24, by targeting the same responsive elements. Since PXR and constitutive androstane receptor (CAR) share responsive elements in the promoter of their target genes, we wondered whether CAR also interferes with CYP24 expression ...
Amélie, Moreau +3 more
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Quantitation of CYP2B6, Constitutive Androstane Receptor, and Pregnane X Receptor mRNA levels
Drug Metabolism and Disposition, 2003We read with great interest, an article in the January 2003 issue of Drug Metabolism and Disposition by [Chang et al. (2003)][1] that described interindividual variability and correlations between CYP2B6 mRNA expression and transcription factor mRNA expression [constitutive androstane receptor ...
Leah M, Hesse, Michael H, Court
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