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High-Content Analysis of Constitutive Androstane Receptor Nuclear Translocation
2019The constitutive androstane receptor (CAR; NR1I3) is a xenobiotic receptor that upregulates metabolism and detoxification mechanisms in the liver in response to chemical stimulation. Drug-induced activation of CAR may result in clinically significant drug-drug interactions and lead to complicated therapeutic outcomes.
Bryan, Mackowiak, Hongbing, Wang
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[Advances in the research of pregnane X receptor and constitutive androstane receptor].
Yao xue xue bao = Acta pharmaceutica Sinica, 2013Nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are originally characterized as transcription factors regulating many target genes. Recent works have revealed that these nuclear receptors play critical roles in regulating genes that encode drug metabolism enzymes and modulating hepatic energy metabolism, such as ...
Bing-fang, Hu, Hui-chang, Bi, Min, Huang
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Functional analysis of four naturally occurring variants of human constitutive androstane receptor
Molecular Genetics and Metabolism, 2005Kouichi Kurose +2 more
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Indirect activation of constitutive androstane receptor in three-dimensionally cultured HepG2 cells
Biochemical Pharmacology, 2019Kosuke Yokobori +2 more
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