Results 151 to 160 of about 5,156 (193)

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain. [PDF]

Cells, 2020
Skoda J, Dusek J, Drastik M, Stefela A, Dohnalova K, Chalupsky K, Smutny T, Micuda S, Gerbal-Chaloin S, Pavek P.   +9 more
europepmc   +1 more source

Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells. [PDF]

Int J Mol Sci, 2020
Goedtke L, Sprenger H, Hofmann U, Schmidt FF, Hammer HS, Zanger UM, Poetz O, Seidel A, Braeuning A, Hessel-Pras S.   +9 more
europepmc   +1 more source

Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis. [PDF]

Toxicol Appl Pharmacol, 2019
Shmarakov IO, Lee YJ, Jiang H, Blaner WS.   +3 more
europepmc   +1 more source

Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor. [PDF]

Sci Rep, 2019
Lukowicz C, Ellero-Simatos S, Régnier M, Oliviero F, Lasserre F, Polizzi A, Montagner A, Smati S, Boudou F, Lenfant F, Guzylack-Pirou L, Menard S, Barretto S, Fougerat A, Lippi Y, Naylies C, Bertrand-Michel J, Belgnaoui AA, Theodorou V, Marchi N, Gourdy P, Gamet-Payrastre L, Loiseau N, Guillou H, Mselli-Lakhal L.   +24 more
europepmc   +1 more source

Small-molecule modulators of the constitutive androstane receptor [PDF]

Expert Opinion on Drug Metabolism and Toxicology, 2015
The constitutive androstane receptor (CAR) induces drug-metabolizing enzymes for xenobiotic metabolism.This review covers recent advances in elucidating the biological functions of CAR and its modulation by a growing number of agonists and inhibitors.Extrapolation of animal CAR function to that of humans should be carefully scrutinized, particularly ...
Sérgio C Chai, Taosheng Chen
exaly   +3 more sources

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An update on the constitutive androstane receptor (CAR)

Drug Metabolism and Drug Interactions, 2013
Abstract The constitutive androstane receptor (CAR; NR1I3) has emerged as one of the main drug- and xenobiotic-sensitive transcriptional regulators. It has a major effect on the expression of several oxidative and conjugative enzymes and transporters, and hence, CAR can contribute to drug/drug interactions. Novel functions for CAR are
Ferdinand Molnár, Jenni Kublbeck, Johanna Jyrkkarinne   +2 more
exaly   +4 more sources

Induction of Constitutive Androstane Receptor during the Development of Oxidative Stress

Bulletin of Experimental Biology and Medicine, 2021
We studied the effect of 3-, 24-, and 72-h exposure to H2O2 in concentrations of 0.1-100.0 μM on the level of constitutive androstane receptor in Caco-2 cells. It was shown that 3- and 24-h incubation with Н2О2 in all concentrations had no effect on the level of constitutive androstane receptors.
A V Shchul'Kin, Yu V Abalenikhina, E N Yakusheva   +2 more
exaly   +3 more sources

Constitutive androstane receptor-responsive elements for mouse Cyp1a2 transcriptional activation induced by constitutive androstane receptor ligands

Drug Metabolism and Pharmacokinetics, 2023
The mouse cytochrome P450 1A2 (Cyp1a2) gene is one of the constitutive androstane receptor (CAR, NR1I3) activator-inducible genes, and the regions involved in induction were examined herein. A reporter gene assay indicated the involvement of the -0.2-kb region in the induction of transcriptional activation by the mouse CAR agonist ligand 1,4-bis-[2-(3 ...
Yuki, Kawasaki, Nobuo, Nemoto, Tsutomu, Sakuma   +2 more
openaire   +2 more sources