Results 1 to 10 of about 19,512 (146)
Modulation of Xenobiotic Receptors by Steroids [PDF]
Molecules, 2013 Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeutic ...
Delira Robbins +2 more
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AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors [PDF]
Cells, 2023 Traditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors.
Leonida Rakateli +2 more
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Xenobiotic receptors in mediating the effect of sepsis on drug metabolism [PDF]
Acta Pharmaceutica Sinica B, 2020 Sepsis is an infection-induced systemic inflammatory syndrome. The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways.
Chuanzhu Lv, Ling Huang
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A brief history of the discovery of PXR and CAR as xenobiotic receptors [PDF]
Acta Pharmaceutica Sinica B, 2016 The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were cloned and/or established as xenobiotic receptors in 1998.
Jiong Yan, Wen Xie
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Xenobiotic Receptors and Their Mates in Atopic Dermatitis [PDF]
International Journal of Molecular Sciences, 2019 Atopic dermatitis (AD) is the most common inflammatory skin disease worldwide. It is a chronic, relapsing and pruritic skin disorder which results from epidermal barrier abnormalities and immune dysregulation, both modulated by environmental factors. AD is strongly associated with asthma and allergic rhinitis in the so-called ‘atopic march’. Xenobiotic
Deborah Minzaghi +2 more
exaly +5 more sources
Oxazaphosphorine bioactivation and detoxification: the role of xenobiotic receptors [PDF]
Acta Pharmaceutica Sinica B, 2012 Oxazaphosphorines, with the most representative members including cyclophosphamide, ifosfamide, and trofosfamide, constitute a class of alkylating agents that have a broad spectrum of anticancer activity against many malignant ailments including both ...
Duan Wang, Hongbing Wang
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Atypical functions of xenobiotic receptors in lipid and glucose metabolism [PDF]
Medical Review, 2022 Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics.
Wang Jingyuan, Lu Peipei, Xie Wen
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Xenobiotic Receptors, a Journey of Rewards. [PDF]
Drug Metab Dispos, 2023 The xenobiotic nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were discovered or characterized in 1998. PXR and CAR have since been defined as master regulators of xenobiotic responses through their transcriptional regulation of drug-metabolizing enzymes and transporters.
Xie W.
europepmc +3 more sources
Activation of xenobiotic receptors: driving into the nucleus. [PDF]
Expert Opin Drug Metab Toxicol, 2010 Xenobiotic receptors (XRs) play pivotal roles in regulating the expression of genes that determine the clearance and detoxification of xenobiotics, such as drugs and environmental chemicals. Recently, it has become increasingly evident that most XRs shuttle between the cytoplasm and nucleus, and activation of such receptors is directly associated with ...
Li H, Wang H.
europepmc +4 more sources
Aspects of xenobiotics and their receptors in stroke
Neuroprotection, 2023 Stroke is devastating and the second leading cause of disability and death worldwide. The pathophysiology of stroke is intricate involving oxidative stress, ionic imbalance, and excitotoxicity leading to cell death. The current therapeutic strategies for
Aishika Datta +5 more
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