Results 21 to 30 of about 19,512 (146)
Odor-evoked transcriptomics of Aedes aegypti mosquitoes.
PLoS ONE, 2023 Modulation of odorant receptors mRNA induced by prolonged odor exposure is highly correlated with ligand-receptor interactions in Drosophila as well as mammals of the Muridae family. If this response feature is conserved in other organisms, this presents
Fredis Mappin +3 more
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Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR)
Acta Pharmaceutica Sinica B, 2021 Crosstalk between xenobiotic metabolism and energy metabolism in the liver has provided a potential opportunity to target xenobiotic receptors to treat metabolic diseases. Activation of constitutive androstane receptor (CAR), a xenobiotic-sensing nuclear
Xinran Cai +4 more
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Physiological activation of human and mouse bitter taste receptors by bile acids
Communications Biology, 2023 Beside the oral cavity, bitter taste receptors are expressed in several non-gustatory tissues. Whether extra-oral bitter taste receptors function as sensors for endogenous agonists is unknown.
Florian Ziegler +3 more
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Pregnane Xenobiotic Receptors and Their Effect on Drug Elimination from the Organism
Prague Medical Report, 2013 Nuclear receptors are intracellular proteins which, having been activated by their more or less specific ligands, regulate (usually increase) the transcription of target genes.
Martin Šíma, I. Netíková, O. Slanař
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CAR and PXR: The xenobiotic-sensing receptors☆ [PDF]
Steroids, 2007 The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their elimination. This unique function of CAR and PXR sets them apart from the steroid hormone receptors. In contrast,
Yoav E, Timsit, Masahiko, Negishi
openaire +2 more sources
Nuclear receptor phosphorylation in xenobiotic signal transduction [PDF]
Journal of Biological Chemistry, 2020 Nuclear pregnane X receptor (PXR, NR1I2) and constitutive active/androstane receptor (CAR, NR1I3) are nuclear receptors characterized in 1998 by their capability to respond to xenobiotics and activate cytochrome P450 (CYP) genes. An anti-epileptic drug, phenobarbital (PB), activates CAR and its target CYP2B genes, whereas PXR is activated by drugs such
Masahiko, Negishi +3 more
openaire +2 more sources
PLoS ONE, 2012 Triclocarban (3,4,4'-trichlorocarbanilide, TCC) is used as a broad-based antimicrobial agent that is commonly added to personal hygiene products. Because of its extensive use in the health care industry and resistance to degradation in sewage treatment ...
Mei-Fei Yueh +4 more
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Acta Pharmaceutica Sinica B, 2022 Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) is well-known to increase drug metabolism and reduce inflammation.
Mallory Little +10 more
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Endocrine disrupting potency of organic pollutant mixtures isolated from commercial fish oil evaluated in yeast-based bioassays. [PDF]
PLoS ONE, 2018 The aim of this work was to evaluate the activity of xenobiotic mixtures containing persistent organic pollutants isolated from commercial fish oil samples against sex hormone receptors, including estrogen and androgen.
Marek Łukasz Roszko +4 more
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Characterization of human oxidoreductases involved in aldehyde odorant metabolism
Scientific Reports, 2023 Oxidoreductases are major enzymes of xenobiotic metabolism. Consequently, they are essential in the chemoprotection of the human body. Many xenobiotic metabolism enzymes have been shown to be involved in chemosensory tissue protection.
Valentin Boichot +12 more
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