The Roles of Xenobiotic Receptors: Beyond Chemical Disposition. [PDF]
Drug Metab Dispos, 2018 Over the past 20 years, the ability of the xenobiotic receptors to coordinate an array of drug-metabolizing enzymes and transporters in response to endogenous and exogenous stimuli has been extensively characterized and well documented. The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are the xenobiotic receptors that have ...
Mackowiak B, Hodge J, Stern S, Wang H.
europepmc +4 more sources
Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde [PDF]
Food Chemistry: Molecular SciencesCinnamon is one of the oldest known spices used in various food delicacies and herbal formulations. Cinnamaldehyde is a primary active constituent of cinnamon and substantially contributes to the food additive and medicinal properties of cinnamon.
Islam Husain +7 more
doaj +2 more sources
Establishment of the H8T-MG Meningioma Cell Line and Integrated Transcriptomics Reveal a Metabolic–Immune Signature in Diploid Transitional WHO Grade 1 Tumours [PDF]
BiomoleculesMeningiomas are the most common intracranial tumours, yet the molecular programs underlying WHO grade 1 subtypes—particularly transitional diploid tumours—remain insufficiently defined, partly due to the scarcity of biologically faithful in vitro models.
Esther Mancheño-Maciá +2 more
doaj +2 more sources
The xenobiotic receptors PXR and CAR in liver physiology, an update [PDF]
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2021 Xinran Cai, Wen Xie
exaly +2 more sources
Crosstalk Between Nutrients and Xenobiotic Receptors
Current Drug Metabolism, 2019 Xi Ma
exaly +3 more sources
The mechanisms of aluminum-induced immunotoxicity in chicks
Poultry Science, 2023 : Aluminum (Al) is a ubiquitous environmental pollutant representing a significant global health hazard to human and animal health, including chicks. Al toxicity causes oxidative stress, leading to tissue injury, and consequently causes various diseases.
Changyu Cao +5 more
doaj +1 more source
Targeting xenobiotic receptors PXR and CAR for metabolic diseases [PDF]
Trends in Pharmacological Sciences, 2012 Wen Xie
exaly +2 more sources
Intestinal microbiota regulate xenobiotic metabolism in the liver. [PDF]
PLoS ONE, 2009 BACKGROUND: The liver is the central organ for xenobiotic metabolism (XM) and is regulated by nuclear receptors such as CAR and PXR, which control the metabolism of drugs.
Britta Björkholm +5 more
doaj +1 more source
Frontiers in Microbiology, 2021 National screening programs use dried blood specimens to detect metabolic disorders or aberrant protein functions that are not clinically evident in the neonatal period.
Anne-Christine Aust +10 more
doaj +1 more source
The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism [PDF]
Nuclear Receptor Signaling, 2009 The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. SXR has an enlarged, flexible, hydrophobic ligand binding domain (LBD) which is remarkably divergent across mammalian ...
Zhou, Changcheng +2 more
openaire +2 more sources