Results 41 to 50 of about 19,512 (146)
Symposium overview: alterations in cytokine receptors by xenobiotics [PDF]
Toxicological Sciences, 1999 A symposium entitled Alterations in Cytokine Receptors by Xenobiotics was held at the 37th Annual Meeting of the Society of Toxicology (SOT) in Seattle, Washington. The symposium was sponsored by the Immunotoxicology Specialty Section of SOT and was designed to present information on the effect of several different classes of xenobiotics on various ...
M D, Cohen +4 more
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PLoS ONE, 2015 Cells cope with the threat of xenobiotic stress by activating a complex molecular network that recognizes and eliminates chemically diverse toxic compounds.
Attila Tóth +4 more
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Regulation of bile acid receptor activity
Liver Research, 2018 Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 ...
Yu-Jui Yvonne Wan, Lili Sheng
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Current trends in drug metabolism and pharmacokinetics
Acta Pharmaceutica Sinica B, 2019 Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is essential for drug development and precision medication.
Yuhua Li +12 more
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Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment
Biomolecules, 2021 Pregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed in normal and malignant tissues. Drug metabolizing enzymes and transporters are
Aikaterini Skandalaki +2 more
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Adaptive and specialised transcriptional responses to xenobiotic stress in Caenorhabditis elegans are regulated by nuclear hormone receptors. [PDF]
PLoS ONE, 2013 Characterisation of the pathways by which xenobiotics are metabolised and excreted in both target and non-target organisms is crucial for the rational design of effective and specific novel bioactive molecules.
Laura M Jones +3 more
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Cells, 2021 Background: PXR is a xenobiotic-responsive nuclear receptor that controls the expression of drug-metabolizing enzymes. Drug-induced activation of PXR sometimes causes drug–drug interactions due to the induced metabolism of co-administered drugs.
Ryota Shizu +6 more
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CYTOCHROME P450 AND XENOBIOTIC RECEPTOR HUMANIZED MICE [PDF]
Annual Review of Pharmacology and Toxicology, 2006 ▪ Abstract Most xenobiotics that enter the body are subjected to metabolism that functions primarily to facilitate their elimination. Metabolism of certain xenobiotics can also result in the production of electrophilic derivatives that can cause cell toxicity and transformation.
Frank J, Gonzalez, Ai-Ming, Yu
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Acta Pharmaceutica Sinica B, 2020 Mutations in genes encoding key players in oncogenic signaling pathways trigger specific downstream gene expression profiles in the respective tumor cell populations.
Albert Braeuning, Michael Schwarz
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Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism
Frontiers in Immunology, 2021 Tryptophan (Trp) is an essential amino acid primarily derived from the diet for use by the host for protein synthesis. The intestinal tract is lined with cells, both host and microbial, that uptake and metabolize Trp to also generate important signaling ...
Heather M. Grifka-Walk +2 more
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