Results 61 to 70 of about 19,512 (146)

PXR: More Than Just a Master Xenobiotic Receptor [PDF]

Molecular Pharmacology, 2018
Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic receptor that coordinately regulates the expression of genes encoding drug-metabolizing enzymes and drug transporters to essentially detoxify and eliminate xenobiotics and endotoxins from the body.
Peter O, Oladimeji, Taosheng, Chen
openaire   +2 more sources

Mechanistic Insights into Mancozeb-Induced Redox Imbalance and Structural Remodelling Affecting the Function of Human Red Blood Cells

Antioxidants
Mancozeb is a broad-spectrum fungicide used extensively in agriculture to protect crops against a wide range of plant diseases. Although its capacity to induce oxidative stress is well documented, the cytotoxic effects of mancozeb on red blood cells ...
Sara Spinelli, Elisabetta Straface, Lucrezia Gambardella, Giuseppina Bozzuto, Daniele Caruso, Angela Marino, Silvia Dossena, Rossana Morabito, Alessia Remigante   +8 more
doaj   +1 more source

Molecular interactions between NAFLD and xenobiotic metabolism

Frontiers in Genetics, 2013
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, is a complex multifactorial disease characterised by metabolic deregulations that include accumulation of lipids in the liver, lipotoxicity and insulin ...
Adviti eNaik, Aleš eBelič, Ulrich M Zanger, Damjana eRozman   +3 more
doaj   +1 more source

Human plasma protein bindings of neonicotinoid insecticides and metabolites

Scientific Reports
Neonicotinoid insecticides (neonicotinoids) are widely used in agriculture, forestry and public health in the world. Environmental exposure to neonicotinoids has been increasing due to their continuous uses.
Kumiko Taira, Yoshinori Ikenaka, Jean-Marc Bonmatin, Anton Safer   +3 more
doaj   +1 more source

PPARα as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds

PPAR Research, 2012
Plants contain potentially toxic compounds for animals and animals have developed physiological strategies to detoxify the ingested toxins during evolution. Feeding mice with various plant seeds and grains showed unexpected result that only sesame killed
Bunichiro Ashibe, Yu Nakajima, Yuka Fukui, Kiyoto Motojima   +3 more
doaj   +1 more source

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers

BMC Genomics, 2009
Background Detoxification in the liver involves activation of nuclear receptors, such as the constitutive androstane receptor (CAR), which regulate downstream genes of xenobiotic metabolism.
Björkhem Ingemar, Lövgren-Sandblom Anita, Tamasi Viola, Režen Tadeja, Meyer Urs A, Rozman Damjana   +5 more
doaj   +1 more source

Tissue-specific effects of benzo[a]pyrene and DDT on microRNA expression profile in female rats

Вавиловский журнал генетики и селекции, 2018
Many xenobiotics in the human environment, such as benzo[a]pyrene (B(a)P) and dichlorodiphenyltrichloroethane (DDT), may act as non-genotoxic carcinogens through epigenetic mechanisms, including changes in microRNA expression profile.
D. S. Ushakov, T. S. Kalinina, A. S. Dorozhkova, V. Y. Ovchinnikov, L. F. Gulyaeva   +4 more
doaj   +1 more source

Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future. [PDF]

Drug Metab Dispos, 2023
Dvořák Z, Li H, Mani S.
europepmc   +1 more source

Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.

PLoS ONE, 2014
The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics.
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel   +6 more
doaj   +1 more source

Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs

PPAR Research, 2013
Fatty acid binding proteins (FABPs) act as intracellular shuttles for fatty acids as well as lipophilic xenobiotics to the nucleus, where these ligands are released to a group of nuclear receptors called the peroxisome proliferator activated receptors ...
Tony Velkov
doaj   +1 more source