Results 51 to 60 of about 19,512 (146)
Modulation of Nuclear Receptor Action and Regulation of Medicines Biotransformation
Антибиотики и Химиотерапия, 2020 Nuclear receptors are transcription factors that are essential in embryonic development, cellular differentiation, metabolism . Ligand-regulated nuclear PXR receptor responds to diverse arrays of chemically distinct ligands , xenobiotics, drugs and ...
S. N. Larina +2 more
doaj
Chicken xenobiotic receptor upregulates the BCRP/ABCG2 transporter
Poultry Science, 2023 : The transporter breast cancer resistance protein (BCRP, encoded by ABCG2) influences the bioavailability and elimination of numerous substrate drugs during clinical therapy.
Ziyong Xu +4 more
doaj +1 more source
Nature CommunicationsConstitutive androstane receptor (CAR) and pregnane X receptor (PXR) are closely related nuclear receptors with overlapping regulatory functions in xenobiotic clearance but distinct roles in endobiotic metabolism.
Jan Dusek +25 more
doaj +1 more source
Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor [PDF]
Experimental Dermatology, 2015 AbstractSkin is in daily contact with potentially harmful molecules from the environment such as cigarette smoke, automobile emissions, industrial soot and groundwater. Pregnane X receptor (PXR) is a transcription factor expressed in liver and intestine that is activated by xenobiotic chemicals including drugs and environmental pollutants.
Andreas, Elentner +6 more
openaire +2 more sources
The intestinal functions of PXR and CAR
Pharmacological ResearchPregnane X receptor (PXR) and constitutive androstane receptor (CAR) are so-called xenobiotic nuclear receptors that play pivotal roles in xenobiotic metabolism and detoxification.
Ye Feng, Jong-Won Kim, Wen Xie
doaj +1 more source
PLoS ONE, 2011 The nuclear receptor superfamily of ligand-activated transcription factors plays a central role in the regulation of cellular responses to chemical challenge. Nuclear receptors are activated by a wide range of both endogenous and exogenous chemicals, and
Ian Bailey +4 more
doaj +1 more source
Conservation of Signaling Pathways of Xenobiotic-Sensing Orphan Nuclear Receptors, Chicken Xenobiotic Receptor, Constitutive Androstane Receptor, and Pregnane X Receptor, from Birds to Humans [PDF]
Molecular Endocrinology, 2001 Chicken xenobiotic receptor, pregnane X receptor, and constitutive androstane receptor are orphan nuclear receptors that have recently been discovered to regulate drug- and steroid-mediated induction of hepatic cytochromes P450 (CYP). This induction is part of an adaptive response involving numerous genes to exposure to drugs and chemicals and has ...
Handschin, C. +4 more
openaire +3 more sources
Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.
PLoS ONE, 2015 Steroid and xenobiotic receptor (SXR) and its murine ortholog, pregnane X receptor (PXR), are nuclear receptors that are expressed at high levels in the liver and the intestine where they function as xenobiotic sensors that induce expression of genes ...
Kotaro Azuma +6 more
doaj +1 more source
Mechanisms of xenobiotic receptor activation: Direct vs. indirect [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016 The so-called xenobiotic receptors (XRs) have functionally evolved into cellular sensors for both endogenous and exogenous stimuli by regulating the transcription of genes encoding drug-metabolizing enzymes and transporters, as well as those involving energy homeostasis, cell proliferation, and/or immune responses.
Bryan, Mackowiak, Hongbing, Wang
openaire +2 more sources
Marine Drugs, 2014 Developing high-throughput assays to screen marine extracts for bioactive compounds presents both conceptual and technical challenges. One major challenge is to develop assays that have well-grounded ecological and evolutionary rationales.
Ingrid Richter, Andrew E. Fidler
doaj +1 more source