Putative Role of the Orphan Nuclear Receptor SXR (Steroid and Xenobiotic Receptor) in the Mechanism of CYP3A4 Inhibition by Xenobiotics [PDF]
Journal of Biological Chemistry, 2002 Cytochrome P450 monooxygenase 3A4 (CYP3A4) is responsible for the metabolism of endogenous steroids and drugs in liver. Many inducers of human CYP3A4, such as rifampicin, bind to the orphan nuclear receptor SXR (steroid and xenobiotic receptor) as ligands and stimulate transcription on xenobiotic response elements located in the CYP3A4 promoter ...
Akira, Takeshita +3 more
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Insights into CYP2B6-mediated drug–drug interactions
Acta Pharmaceutica Sinica B, 2016 Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed. The discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the ...
William D. Hedrich +2 more
doaj +1 more source
Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity
Acta Pharmaceutica Sinica B, 2022 Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been explored.
Youbo Zhang +15 more
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Regulation of Xenobiotic Metabolism by Orphan Nuclear Receptors [PDF]
Toxicologic Pathology, 2001 Nuclear receptors control gene transcription by binding to specifi cpromoter regions of DNA in the presence of ligand. Orphan nuclear receptors are nuclear receptors for which the endogenous ligand(s) has yet to be identified. Systematic evaluation of orphan nuclear receptors can elucidate species differences in xenobiotic metabolism in addition to ...
R T, Miller, T M, Willson
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Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice. [PDF]
PLoS ONE, 2013 Xenobiotic-responsive nuclear receptors pregnane X receptor (PXR), constitutive active/androstane receptor (CAR) and peroxisome proliferator-activated receptor α (PPARα) play pivotal roles in the metabolic functions of the liver such as xenobiotics ...
Ryota Shizu +6 more
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Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
Cells, 2020 During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug- and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules ...
Jenni Küblbeck +2 more
doaj +1 more source
Macrophage nuclear receptors: Emerging key players in infectious diseases. [PDF]
PLoS Pathogens, 2019 Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a variety of cells, including macrophages. For decades, NRs have been therapeutic targets because their activity can be pharmacologically modulated by specific ...
Chrissy M Leopold Wager +2 more
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Role of the xenobiotic receptor in inflammatory bowel disease [PDF]
Inflammatory Bowel Diseases, 2011 Gene-environment interplay modulates inflammatory bowel diseases (IBD). Dioxin-like compounds can activate the aryl hydrocarbon receptor (AhR) and alter macrophage function as well as T-cell polarization. We hypothesized that attenuation of the AhR signaling pathway will ameliorate colitis in a murine model of IBD.Dextran sulfate sodium (DSS) colitis ...
Razvan, Arsenescu +7 more
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Chemical Artificial Internalizing Receptors for Primary T Cells
Advanced Science, 2020 The newest generation of cell‐based technologies relies heavily on methods to communicate to the engineered cells using artificial receptors, specifically to deactivate the cells administered to a patient in the event of adverse effects.
Pere Monge +5 more
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Roles of Xenobiotic Receptors in Vascular Pathophysiology
Circulation Journal, 2014 The pregnane X receptor (PXR) and constitutive androstane receptor (CAR), 2 closely related and liver-enriched members of the nuclear receptor superfamily, and aryl hydrocarbon receptor (AhR), a nonnuclear receptor transcription factor (TF), are major receptors/TFs regulating the expression of genes for the clearance and detoxification of xenobiotics ...
Xiao, Lei, Zhang, Zihui, Luo, Xiaoqin
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