Results 191 to 200 of about 45,599 (229)

Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation

Drug Metabolism And Disposition, 2020
UDP-glucuronosyltransferase (UGT) 1A1 is the only transferase capable of conjugating serum bilirubin. However, temporal delay in the development of the UGT1A1 gene leads to an accumulation of serum bilirubin in newborn children.
A. Weber, Elvira Mennillo, Xiaojing Yang, Lori W E van der Schoor, J. Jonker, Shujuan Chen, R. Tukey   +6 more
semanticscholar   +1 more source

The Constitutive Active/Androstane Receptor Regulates Phenytoin Induction of Cyp2c29

Molecular Pharmacology, 2004
Many cytochrome P450 isoforms are known to be drug-inducible. The anticonvulsant phenytoin has been reported to be an inducer of human CYP2B6, CYP3A4, and murine CYP2C29. However, the molecular mechanism mediating phenytoin induction remains unclear.
Jonathan P, Jackson, Stephen S, Ferguson, Rick, Moore, Masahiko, Negishi, Joyce A, Goldstein   +4 more
openaire   +2 more sources

Constitutive Androstane Receptor Expression in the Rat Cervix During Gestation

Journal of the Society for Gynecologic Investigation, 2000
To investigate expression of the constitutive androstane receptor (CAR) in the pregnant rat cervix.Rat uterine tissue was obtained on gestational days 12, 16, 20, 21, and 22 (the day of parturition), and postpartum day 1. In addition, liver, lung, kidney, heart, and skeletal muscle tissue were obtained.
D F, Rychlik, E, Bieber, M, Phillippe
openaire   +2 more sources

Induction of Constitutive Androstane Receptor during the Development of Oxidative Stress

Bulletin of experimental biology and medicine, 2021
A. V. Shchul’kin, Y. Abalenikhina, A. A. Seidkulieva, A. Ryabkov, E. Yakusheva   +4 more
semanticscholar   +1 more source

Role of the constitutive androstane receptor (CAR) in human liver cancer.

Biochimica et biophysica acta. Reviews on cancer, 2021
S. Bae, Romario Nguyen, L. Qiao, J. George   +3 more
semanticscholar   +1 more source

Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice.

Biochemical Pharmacology, 2021
J. Škoda, Klára Dohnalová, K. Chalupský, A. Stahl, M. Templin, J. Maixnerová, S. Mičuda, Lars Grøntved, A. Braeuning, P. Pávek   +9 more
semanticscholar   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Breast Cancer Statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Hyuna Sung, Kimberly D Miller, Rebecca L Siegel   +2 more
exaly  

Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse

Archives of Toxicology, 2020
Zemin Wang, Qiangen Wu, Xi-lian Li, J. Klaunig   +3 more
semanticscholar   +1 more source

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly