Results 41 to 50 of about 156,172 (278)

Macroscopic Entropy of Non-Equilibrium Systems and Postulates of Extended Thermodynamics: Application to Transport Phenomena and Chemical Reactions in Nanoparticles

Entropy, 2018
In this work, we consider extended irreversible thermodynamics in assuming that the entropy density is a function of both common thermodynamic variables and their higher-order time derivatives.
Sergey I. Serdyukov
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Constitutive Equations for a Simulator of Airlift Pump in a Large Diameter Pipe using Drift-Flux Model

Journal of MMIJ, 2018
One of the authors has developed a numerical simulator of airlift pump to solve governing equations represented by the drift flux model. The solver is based on the finite volume method which is known as SIMPLER algorithm for numerical scheme.
Nobuo HATAKEYAMA, Yoshiyuki SHIMIZU, Tadashi MASUYAMA   +2 more
doaj   +1 more source

A Comparative Study on Arrhenius Equations and BP Neural Network Models to Predict Hot Deformation Behaviors of a Hypereutectoid Steel

IEEE Access, 2020
In order to predict the high-temperature deformation behavior of hypereutectoid steel, the hot compression tests were conducted in the strain rate range of (0.001~1) s-1 and the deformation temperature range of (950~1100)°C.
Ling Qiao, Yong Deng, Yuan Wang, Jingchuan Zhu   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A unified constitutive relationship with the internal state variables of grain evolution behavior and the application in numerical simulation of cross wedge rolling

Journal of Materials Research and Technology, 2022
Controlling the grain size is an essential issue in the metal plastic working processes. Based on the consensus view that grain boundaries are impassable borders for dislocations and that the number of dislocations within a grain affects the stress ...
Jing Zhou, Xiaoqing Cao, Jinxia Shen, Baoyu Wang   +3 more
doaj   +1 more source

Extended concept of representative directions to describe inelastic behaviour of electrospun polymers [PDF]

, 2019
The concept of representative directions allows one to generalize onedimensional uniaxial material models to more general constitutive equations, suitable for arbitrary multi-axial loading scenarios.
Shutov, Alexey V.
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Strain-Rate and Stress-Rate Models of Nonlinear Viscoelastic Materials

Mathematics
The paper is devoted to the modeling of nonlinear viscoelastic materials. The constitutive equations are considered in differential form via relations between strain, stress, and their derivatives in the Lagrangian description.
Claudio Giorgi, Angelo Morro
doaj   +1 more source