Results 61 to 70 of about 35,760 (296)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Predicting the flow stress behavior of Ni-42.5Ti-3Cu during hot deformation using constitutive equations

, 2013
The hot deformation behavior of ternary Ni-42.5Ti-3Cu alloy was modeled. Hot compression tests were carried out at the temperatures from 800°C to 1000°C and at the strain rates of 0.001 s−1 to 1 s−1.
Dehghani, Kamran, Ebrahimi, G. R., Etaati, Amir, Wang, Hao   +3 more
core   +1 more source

Prediction of High Temperature Flow Stress of Alloy 2618-Ti during Hot Deformation

High Temperature Materials and Processes, 2015
In order to find material parameters of established Zener-Hollomon constitutive equations and predict high-temperature flow stress of alloy 2618-Ti, the hot compressive deformation behaviors of the alloy were investigated at temperatures ranging from 300
Liu Ya, Li Jing, Song Yuanfeng, Li Tao, Su Xuping, Wang Jianhua   +5 more
doaj   +1 more source

Two-dimensional Nye figures for hemitropic micropolar elastic solids [PDF]

Известия Саратовского университета. Новая серия: Математика. Механика. Информатика
The paper is devoted to a wide range of problems related to the two-dimensional Nye figures for micropolar continua. The method of two-dimensional matrix representation of fourth-rank tensors is well known from monographs on crystallography.
Murashkin, Evgenii Valeryevich, Radayev, Yuri Nickolaevich   +1 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Constitutive Equations for Magnetic Active Liquids

, 2021
This article is focused on the derivation of constitutive equations for magnetic liquids. The results can be used for both ferromagnetic and magnetorheological fluids after the introduced simplifications.
Fialová, Simona, Simona Fialová, František Pochylý, Pochylý, František   +3 more
core   +1 more source

Thermodiffusion in Elastic Materials of Grade Two

Engineering Transactions, 1979
The elastic solid of grade two subjected to the process of thermodiffusion is studied in the framework of the nonlinear mechanics of continua. Two independent sets of constitutive quantities are obtained: the first set results from the free energy ...
N. Naerlović-Veljković, M. Plavsić
doaj  

On the constitutive equations of fresh mortar

Journal of the Mechanical Behavior of Materials, 2016
A preliminary constitutive model is suggested for fresh mortar by taking into account the rheological properties of the base matrix (concrete matrix), as well as the interaction of the aggregates (concrete suspensions).
Kakavas P.A., Konstantinidis A., Hatzitrifon N.K., Papadopoulos P., Aifantis E.C.   +4 more
doaj   +1 more source

Constitutive modelling of hot deformation behaviour of a CoCrFeMnNi high-entropy alloy

Science and Technology of Advanced Materials, 2020
Models describing the constitutive flow behaviour of a metallic material are desired for appropriate process design and realization of defect-free components.
Madan Patnamsetty, Ari Saastamoinen, Mahesh C. Somani, Pasi Peura   +3 more
doaj   +1 more source