Results 71 to 80 of about 35,760 (296)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effect of Constitutive Equations on Springback Prediction Accuracy in the TRIP1180 Cold Stamping

Metals, 2017
This study aimed to evaluate the effect of constitutive equations on springback prediction accuracy in cold stamping with various deformation modes. This study investigated the ability of two yield functions to describe the yield behavior: Hill’48 and ...
Ki-Young Seo, Jae-Hong Kim, Hyun-Seok Lee, Ji Hoon Kim, Byung-Min Kim   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Nonlinear constitutive equations for gravitoelectromagnetism

, 2014
This paper studies nonlinear constitutive equations for gravitoelectromagnetism. Eventually, the problem is solved of finding, for a given particular solution of the gravity- Maxwell equations, the exact form of the corresponding nonlinear constitutive
ESPOSITO G, KOTVYTSKIY A, DUPLIJ S, DI GREZIA E   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Preliminary analysing of experimental data for the development of high Cr Alloy Creep damage Constitutive Equations

, 2012
This conference paper presents the current research of preliminary analysing of experimental data for the development of high Cr Alloy Creep damage Constitutive Equations (such as P91 alloy). Firstly, it briefly introduces the background of general creep
Xu, Qiang, An, Li Li, Xu, Donglai, An, Lili, Lu, Zhongyu   +4 more
core  

On the modelling of highly elastic flows of amorphous thermoplastics

, 2009
Two approaches to the kinematic structuring of constitutive models for highly elastic flows of polymer melts have been examined systematically, assuming either: (1) additivity of elastic and viscous velocity gradients or (2) multiplicability of elastic ...
Buckley, Christopher, C. Paul Buckley, Buckley, CP, Figiel, Lukasz, Buckley, C., Lukasz Figiel, Figiel, L   +6 more
core   +1 more source

Constitutive equations of AA6111 aluminum alloy

Metalurgija, 2019
The hot compression test was conducted in Gleeble-1 500D to study the hot flow stress behavior of AA6 111 aluminum alloy belonging to Al-Mg-Si series, at the deformation temperatures ranging from 350 to 500 °C and strain rates ranging from 0,01 s-1 to 1 ...
B. Z. Wang, X. M. Huang, C. Wang, Z. Y. Wang, C. Xing, H. C. Ji   +5 more
doaj  

Elastic analysis of uniform pressurized axisymmetric cylindrical shells made of saturated porous materials

Results in Physics
In this present research, for the first time, the elastic analysis of uniform pressurized axisymmetric cylindrical shells made of saturated porous materials is studied.
Hooman Esfandyari, Mohammad Zamani Nejad
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source