Results 41 to 50 of about 157,229 (275)

Closed form solution of the return mapping algorithm in elastoplasticity [PDF]

, 2017
In the present work a return mapping algorithm is discussed for small strain elastoplasticity boundary value problems with an exact closed form solution of the local constitutive equations.
De Angelis, Fabio, Taylor, Robert L.
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Constitutive Equations for a Simulator of Airlift Pump in a Large Diameter Pipe using Drift-Flux Model

Journal of MMIJ, 2018
One of the authors has developed a numerical simulator of airlift pump to solve governing equations represented by the drift flux model. The solver is based on the finite volume method which is known as SIMPLER algorithm for numerical scheme.
Nobuo HATAKEYAMA, Yoshiyuki SHIMIZU, Tadashi MASUYAMA   +2 more
doaj   +1 more source

A Comparative Study on Arrhenius Equations and BP Neural Network Models to Predict Hot Deformation Behaviors of a Hypereutectoid Steel

IEEE Access, 2020
In order to predict the high-temperature deformation behavior of hypereutectoid steel, the hot compression tests were conducted in the strain rate range of (0.001~1) s-1 and the deformation temperature range of (950~1100)°C.
Ling Qiao, Yong Deng, Yuan Wang, Jingchuan Zhu   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Strain-Rate and Stress-Rate Models of Nonlinear Viscoelastic Materials

Mathematics
The paper is devoted to the modeling of nonlinear viscoelastic materials. The constitutive equations are considered in differential form via relations between strain, stress, and their derivatives in the Lagrangian description.
Claudio Giorgi, Angelo Morro
doaj   +1 more source

A unified constitutive relationship with the internal state variables of grain evolution behavior and the application in numerical simulation of cross wedge rolling

Journal of Materials Research and Technology, 2022
Controlling the grain size is an essential issue in the metal plastic working processes. Based on the consensus view that grain boundaries are impassable borders for dislocations and that the number of dislocations within a grain affects the stress ...
Jing Zhou, Xiaoqing Cao, Jinxia Shen, Baoyu Wang   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Entropy Analysis for a Nonlinear Fluid with a Nonlinear Heat Flux Vector

Entropy, 2017
Flowing media in both industrial and natural processes are often characterized as assemblages of densely packed granular materials. Typically, the constitutive relations for the stress tensor and heat flux vector are fundamentally nonlinear.
Hyunjin Yang, Mehrdad Massoudi, A. D. Kirwan   +2 more
doaj   +1 more source