Results 81 to 90 of about 736,297 (294)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Numerical investigations on constitutive model parameters of HRB400 and HTRB600 steel bars based on tensile and fatigue tests

Reviews on Advanced Materials Science
In recent years, HRB400 and HTRB600 steel bars have become the mainstream standard reinforcing steel used in concrete structures in China. However, significant controversy still exists regarding the selection of material constitutive models and the ...
Zhu Hanbo, Deng Jibing, Zhuang Mei-Ling, Sun Chuanzhi, Gao Li, Shao Yuefeng, Wang Mingsen, Wang Youzhi, Dong Yao-Rong, Tong Lei   +9 more
doaj   +1 more source

Constitutive modeling of superalloy single crystals with verification testing [PDF]

The goal is the development of constitutive equations to describe the elevated temperature stress-strain behavior of single crystal turbine blade alloys.
Jordan, Eric, Walker, Kevin P.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

STUDY ON TWO-SCALE UNIFIED CONSTITUTIVE MODEL AND DAMPING MECHANISM OF RUBBER CONVEYOR BELT WITH STEEL WIRE ROPE CORE

Jixie qiangdu
Constitutive analysis of steel wire rope conveyor belt is a key problem for conveyor belt design optimization and energy conservation. Maxwell model and Burgers model based on viscoelastic theory and transient dynamics were constructed.
LI Jiangang, FENG Jinping, WANG Xin, LIU Siyuan, GAO Zhongjie, WU Jianjun   +5 more
doaj   +2 more sources

Compressive damage constitutive model for brittle coal based on the compaction effect and linear energy dissipation law

International Journal of Coal Science & Technology
The study of the mechanical property and damage state of coal materials under compression is a fundamental area of research in underground mining engineering. Drawing upon the compaction effect and linear energy dissipation (LED) law, a novel compressive
Fengqiang Gong, Lei Xu, Mingzhong Gao, Yingjie Zhao, Peilei Zhang   +4 more
doaj   +1 more source

Method to determine the optimal constitutive model from spherical indentation tests

Results in Physics, 2018
The limitation of current indentation theories was investigated and a method to determine the optimal constitutive model through spherical indentation tests was proposed.
Tairui Zhang, Shang Wang, Weiqiang Wang
doaj   +1 more source

Some consequences of stress range dependent constitutive models in creep [PDF]

, 2010
Studies of the behaviour of structural components at high temperature subject to creep have a long history and their behavioural characteristics, certainly for constant and cyclic load, well established.
Boyle, James
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source