Results 61 to 70 of about 20,298 (293)

Rabbit models of heart disease. [PDF]

, 2008
Human heart disease is a major cause of death and disability. A variety of animal models of cardiac disease have been developed to better understand the etiology, cellular and molecular mechanisms of cardiac dysfunction and novel therapeutic strategies ...
Bers, Donald M, Pogwizd, Steven M
core  

Identification of differentially expressed genes and preliminary validations in cardiac pathological remodeling induced by transverse aortic constriction

International Journal of Molecular Medicine, 2019
Cardiac remodeling predisposes to heart failure if the burden is unresolved, and heart failure is an important cause of mortality in humans. The aim of the present study was to identify the key genes involved in cardiac pathological remodeling induced by pressure overload.
Li-bo Liu, Di Fan, Si‑Hui Huang, Man Xu, Qi-Zhu Tang, Ming‑Xin Liu, Rong Huang, Kang Yang, Hui‑Bo Wang, Hai‑Ming Wu   +9 more
openaire   +4 more sources

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

Plastias de estenoses de intestino delgado na doença de Crohn: resultados imediatos e tardios Crohn’s disease small bowel strictureplasties: early and late results

Arquivos de Gastroenterologia, 2007
RACIONAL: As enteroplastias constituem alternativa cirúrgica no tratamento da estenose da doença de Crohn. OBJETIVO: Analisar, retrospectivamente, a evolução precoce e tardia do tratamento cirúrgico das estenoses do intestino delgado, segmento ileocecal ...
Maria de Lourdes Setsuko Ayrizono, Raquel Franco Leal, Cláudio Saddy Rodrigues Coy, João José Fagundes, Juvenal Ricardo Navarro Góes   +4 more
doaj   +1 more source

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Wafer‐Scale Integration of α‐quartz Thin Films toward Super High Frequency Piezoelectric bioNEMS for Chikungunya Virus Detection

Advanced Functional Materials, EarlyView.
Epitaxial piezoelectric α‐quartz/Si BioNEMS sensors, made using soft chemistry, effectively detect the Chikungunya virus. They have a mass sensitivity of 205 pg Hz−1 in liquid and can detect the virus at a limit of 9 ng mL−1. This development enables high‐frequency mass devices for point‐of‐care testing in healthcare and other electronic applications ...
Raissa Rathar, Sijie Ding, David Sanchez‐Fuentes, Claire Jolly, Charlotte André‐Arpin, Rudy Desgarceaux, Nicolas Guillaume, Gustavo Ardila, Ricardo Garcia‐Bermejo, Jaume Gazquez, Sergi Plana‐Ruiz, Laura Picas, Adrian Carretero‐Genevrier   +12 more
wiley   +1 more source

Estenose idiopática de traquéia: relato de quatro casos Idiopathic tracheal stenosis: a report of four cases

Jornal Brasileiro de Pneumologia, 2007
A estenose idiopática de traquéia é incomum. Relatam-se quatro casos com quadro clínico semelhante: história de tratamento de broncoespasmo sem resultado e diagnóstico por broncoscopia. O tratamento em três pacientes foi dilatação e corticóide sistêmico;
Carolina Rossi, Fernanda Colombari, Alda Losi Guembarowsky, Olavo Franco Ferreira Filho, João Carlos Thomson   +4 more
doaj   +1 more source

Progressive induction of left ventricular pressure overload in a large animal model elicits myocardial remodeling and a unique matrix signature [PDF]

, 2012
ObjectivePatients with severe left ventricular pressure overload secondary to aortic stenosis can present with signs and symptoms of heart failure despite normal left ventricular ejection fraction.
Dixon, Jennifer A., Eckhouse, Shaina R., Ikonomidis, John S., Mukherjee, Rupak, Oelsen, J. Marshall, Rivers, William T., Spinale, Francis G., Stroud, Robert E., Yarbrough, William M., Zile, Michael R.   +9 more
core   +1 more source

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

Advanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse, Qian Peter Su, Daniele Vigolo, Mike Chia Lun Wu, Lining Arnold Ju   +13 more
wiley   +1 more source

MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts. [PDF]

PLoS ONE, 2013
Downregulation of the muscle-specific microRNA-1 (miR-1) mediates the induction of pathologic cardiac hypertrophy. Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular ...
Antonio Curcio, Daniele Torella, Claudio Iaconetti, Eugenia Pasceri, Jolanda Sabatino, Sabato Sorrentino, Salvatore Giampà, Mariella Micieli, Alberto Polimeni, Beverley J Henning, Angelo Leone, Daniele Catalucci, Georgina M Ellison, Gianluigi Condorelli, Ciro Indolfi   +14 more
doaj   +1 more source