Results 61 to 70 of about 5,827,116 (403)

Random sets and exact confidence regions [PDF]

open access: yes, 2013
An important problem in statistics is the construction of confidence regions for unknown parameters. In most cases, asymptotic distribution theory is used to construct confidence regions, so any coverage probability claims only hold approximately, for ...
Martin, Ryan
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Socioemotional Wealth (SEW): Questions on Construct Validity

open access: yes, 2019
Over the past decade and a half, there has been tremendous growth in the family business field of study. One of the most important developments during this time period is the concept of socioemotional wealth (SEW), which is primarily founded on the ...
Keith H. Brigham, G. Tyge Payne
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

The Online Student Connectedness Survey: Evidence of Initial Construct Validity

open access: yesInternational Review of Research in Open and Distributed Learning, 2017
The Online Student Connectedness Survey (OSCS) was introduced to the academic community in 2012 as an instrument designed to measure feelings of connectedness between students participating in online degree and certification programs. The purpose of this
Tekeisha Denise Zimmerman, Kim Nimon
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Construction of an instrument for evaluating the teaching process in higher education: Content and construct validity

open access: yesREID (Research and Evaluation in Education)
This study aims to reveal the content validity, construct validity, and reliability of the instrument for evaluating the teaching process in higher education. This research is development research applying the ADDIE model from Molenda.
Risky Setiawan   +2 more
doaj   +1 more source

Development of a women’s empowerment index for Tanzania from the demographic and health surveys of 2004–05, 2010, and 2015–16

open access: yesEmerging Themes in Epidemiology, 2021
Background Women’s empowerment is a multidimensional construct which varies by context. These variations make it challenging to have a concrete definition that can be measured quantitatively.
Andrew Evarist Mganga   +4 more
doaj   +1 more source

Statistical concerns, invalid construct validity, and future recommendations

open access: yesNursing Practice Today, 2023
The need for accurate measurement of constructs and understanding of diverse phenomena has prompted researchers to investigate the validity and reliability of developed measures in a continuous effort to improve our understanding of their psychometric ...
Hamid Sharif-Nia   +5 more
doaj   +1 more source

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