Results 91 to 100 of about 2,587 (272)

Constant depth microfluidic networks based on a generalised Murray’s law for Newtonian and power-law fluids [PDF]

, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014), Barber, RW, Emerson, DR, Oliveira, MSN, Zografos, K   +4 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Geometric optimization of bodies submitted to an intense heat flux using bifurcated channel nets

Vetor, 2010
The present work studies the geometric optimization of a body submitted to intense heat flux. The body to be optimized is refrigerated by a ducts system whose circulating fluid will remove the heat.
Claus de Rosso Bolzan, Elizaldo Domingues dos Santos, Liercio André Isoldi, Luiz Alberto Oliveira Rocha   +3 more
doaj   +4 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Engineering Flow and Design [PDF]

, 2015
The importance of design in natural and engineered flow systems is undisputed. It is not only essential to life, but also plays a crucial role in our technological world.
Miguel, A. F., Rocha, Luiz, Öchsner, Andreas   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Geometric Evaluation of Stiffened Steel Plates Subjected to Transverse Loading for Naval and Offshore Applications

Journal of Marine Science and Engineering, 2019
This work searched for the optimal geometrical configuration of simply supported stiffened plates subjected to a transverse and uniformly distributed load.
João Pedro T. P. de Queiroz, Marcelo L. Cunha, Ana Pavlovic, Luiz Alberto O. Rocha, Elizaldo D. dos Santos, Grégori da S. Troina, Liércio A. Isoldi   +6 more
doaj   +1 more source

Constructal Optimizations of Line-to-Line Vascular Channels with Turbulent Convection Heat Transfer. [PDF]

Entropy (Basel), 2022
Lin D, Xie Z, Nan G, Jiang P, Ge Y.
europepmc   +1 more source

Elaboration d'une structure de collecte des déchets organiques à l'aide de la théorie constructale [PDF]

, 2014
International audienceLa gestion des déchets présente des enjeux économiques et environnementaux majeurs pour nos sociétés, et notamment sur la question des transports.
Al-Maalouf, George, Glaus, Mathias, Hausler, Robert, Laforest, Valérie, Tanguy, Audrey   +4 more
core   +1 more source