Survivin and Aurora Kinase A control cell fate decisions during mitosis
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Fitting new constructal models for the thermal potential of earth-air heat exchangers
Relying on the Constructal Design method, this paper introduces new periodic models for the thermal potential of Earth-Air Heat Exchangers (Eahe). As a case study, it analyses the best spacing for three ducts arranged triangularly in order to maximize ...
Jairo Valões de Alencar Ramalho +5 more
doaj +1 more source
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
An assessment of branching asymmetry of the tracheobronchial tree. [PDF]
Miguel AF.
europepmc +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Constructal Design of Elliptical Cylinders with Heat Generating for Entropy Generation Minimization. [PDF]
Wang R, Xie Z, Yin Y, Chen L.
europepmc +1 more source
Constructal Optimization of Rectangular Microchannel Heat Sink with Porous Medium for Entropy Generation Minimization. [PDF]
Li W, Xie Z, Xi K, Xia S, Ge Y.
europepmc +1 more source
Rethinking evolution, entropy and economics: A triadic conceptual framework for the maximum entropy principle as applied to the growth of knowledge [PDF]
Recently, the maximum entropy principle has been applied to explain the evolution of complex non-equilibrium systems, such as the Earth system. I argue that it can also be fruitfully deployed to reconsider the classical treatment of entropy in economics ...
Herrmann-Pillath, Carsten
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source

