Results 111 to 120 of about 2,587 (272)

Flow Evolution in Magmatic Conduits: A Constructal Law Analysis of Stochastic Basaltic and Felsic Lava Dynamics

Fluids
This study probabilistically assesses magma ascent by modeling dike propagation as a fully coupled fluid-flow, thermo-mechanical problem, explicitly accounting for the stochastic heterogeneity of the crustal host rock.
Antonio F. Miguel, Vinícius R. Pepe, Luiz A. O. Rocha   +2 more
doaj   +1 more source

Constructal Design of an Arrow-Shaped High Thermal Conductivity Channel in a Square Heat Generation Body. [PDF]

Entropy (Basel), 2020
Zhang F, Feng H, Chen L, You J, Xie Z.
europepmc   +1 more source

Thermodynamics 2.0: Bridging the natural and social sciences. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Poudel R, McGowan J, Georgiev GY, Haven E, Gunes U, Zhang H.   +5 more
europepmc   +1 more source

Simultaneous Extrema in the Entropy Production for Steady-State Fluid Flow in Parallel Pipes

, 2010
Steady-state flow of an incompressible fluid in parallel pipes can simultaneously satisfy two contradictory extremum principles in the entropy production, depending on the flow conditions.
Andresen, Ang, Attard, Attard, Awumah, Bejan, Bejan, Bruers, Christen, Christen, Crooks, Dewar, Dewar, Dewar, Helmholtz, Jaynes, Juretic, Kleidon, Landauer, Main, Martyushev, Martyushev, Martyushev, Meysman, Niven, Niven, Niven, Niven, Nulton, Onsager, Onsager, Onsager, Ozawa, Salamon, Salamon, Schneider, Setiadi, Županovic   +37 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

and Development, from the Individual Researcher to research Empires [PDF]

, 2012
This paper is dated: it was written at the time of the celebration of the 20 years of activity of the Évora Geophysics Centre (CGE). It comprises a brief appraisal of the evolution of scientific research in Europe and in the United States of America ...
Reis, A. Heitor
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Computational Model and Constructal Design Applied to Thin Stiffened Plates Subjected to Elastoplastic Buckling Due to Combined Loading Conditions

Applied Sciences
The size of ships has increased considerably in recent decades. This growth impacts the stress magnitude in the bottom hull plates, which constantly suffer from biaxial compression and lateral water pressure, potentially leading to buckling.
Raí Lima Vieira, Guilherme Ribeiro Baumgardt, Elizaldo Domingues dos Santos, Luiz Alberto Oliveira Rocha, Thiago da Silveira, João Paulo Silva Lima, Liércio André Isoldi   +6 more
doaj   +1 more source

Tree-Shaped Fluid Flow and Heat Transfe [PDF]

, 2018
This book is an attempt to present a comprehensive overview of the fundamentals in the area of tree flow networks. Emphasis is placed on the understanding of the design features of these networks and on their significance to the transport phenomena ...
Miguel, A. F., Rocha, L. A. O.
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source