Results 71 to 80 of about 2,587 (272)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
“Recent Advances in Energy Research” [PDF]
, 2008 The worldwide scarcity of fossil fuels regarding primary energy demand together with growing environmental concerns have raised new challenges to the world economy, and led to changes in the energy paradigm.
Miguel, A. F., Reis, A. Heitor
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Branching in fluidic networks with permeable walls: an extension of Hess-Murray’s law [PDF]
, 2017 The branching of fluidic networks becomes a subject of great interest due to its importance in understanding the behavior of branching networks in biology (cardiovascular and bronchial systems, river basins, the structure of plants and trees, etc..), as ...
Miguel, A. F. +2 more
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Vetor, 2016 Este estudo numérico utiliza o método Constructal Design para reduzir os pontos quentes de um sistema com geração de calor uniforme por unidade de volume através da transferência de calor por condução.
Cássia Cris Beckel +3 more
doaj +4 more sources
Constructal design for a clover-shaped high conductivity channel in a square heat generating body
Case Studies in Thermal EngineeringConstructal design of a square heat generating body with a clover-shaped high thermal conductivity channel is carried out. The research focuses on minimizing the maximum temperature difference and the entropy generation rate by releasing degrees of ...
Lingen Chen +4 more
doaj +1 more source
A design rule for constant depth microfluidic networks for power-law fluids [PDF]
, 2015 A biomimetic design rule is proposed for generating bifurcating microfluidic channel networks of rectangular cross section for power-law and Newtonian fluids.
Barber, Robert W. +3 more
core +1 more source