Results 71 to 80 of about 2,613 (292)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Mathematical model of a constructal Coanda effect nozzle [PDF]
, 2016 This paper analyses the ACHEON Coanda effect nozzle for aircraft propulsion, based on the dynamic equilibrium of two jet streams. The ACHEON concept, and, in particular, the HOMER nozzle, which is its main component, are presented, together with the ...
Angeli, Diego +3 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Branching in fluidic networks with permeable walls: an extension of Hess-Murray’s law [PDF]
, 2017 The branching of fluidic networks becomes a subject of great interest due to its importance in understanding the behavior of branching networks in biology (cardiovascular and bronchial systems, river basins, the structure of plants and trees, etc..), as ...
Miguel, A. F. +2 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Vetor, 2016 Este estudo numérico utiliza o método Constructal Design para reduzir os pontos quentes de um sistema com geração de calor uniforme por unidade de volume através da transferência de calor por condução.
Cássia Cris Beckel +3 more
doaj +4 more sources
Constructal design for a clover-shaped high conductivity channel in a square heat generating body
Case Studies in Thermal EngineeringConstructal design of a square heat generating body with a clover-shaped high thermal conductivity channel is carried out. The research focuses on minimizing the maximum temperature difference and the entropy generation rate by releasing degrees of ...
Lingen Chen +4 more
doaj +1 more source
Challenges and progress on the modelling of entropy generation in porous media: a review [PDF]
, 2017 Depending upon the ultimate design, the use of porous media in thermal and chemical systems can provide significant operational advantages, including helping to maintain a uniform temperature distribution, increasing the heat transfer rate, controlling ...
Karimi, Nader +3 more
core +1 more source